上海地区中老年人维生素D与骨密度之间的相关性调查
Investigation of the correlation between vitamin D and bone mineral density in middle-aged and elder people in Shanghai
  
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中文关键词:  维生素D  骨密度  骨质疏松
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赵海洋1 朱建民2 张银网2 1.江苏大学临床医学院,镇江 2.上海市徐汇区中心医院骨科,上海200031 
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中文摘要:
      目的研究维生素D与骨密度的相关性。方法调查248名自由居住在上海的中老年人,女性128名,男性120名,年 龄在40到90之间,他们都是从人口基数中随机选人的。分别测量选人对象的全身骨密度和血清中25( OH)D的含量,分析两 者之间的相关性。结果研究对象的平均年龄70.03 ±11.44岁,其中男性的平均年龄为70.96 ±12.22岁,女性的平均年龄 为69. 16 ± 10. 62岁。研究对象的平均25 ( OH) D的总量浓度为13. 733 ± 6. 894 ng/ml;平均25 ( OH) D2的浓度为1. 672 士 1.577 ng/ml,平均25(OH)D3 的浓度为 12.057 ±6.631 ng/ml。其中男性平均25(OH)D 的总量浓度为 14. 258 ±5. 557 ng/ml; 平均 25 (OH) D2 的浓度为 1. 580 ± 1. 548 ng/ml,平均 25( OH) D3 的浓度为 12.710±5.440 ng/ml。女性平均 25( OH) D 的总量 浓度为 13.241 ±7. 937 ng/ml;平均 25( OH) D2 的浓度为 1.58 ±1.604 ng/ml,平均 25( OH) D3 的浓度为 11.445 ±7.550 ng/ ml。研究对象中97%(n =241)25( OH) D的浓度小于30 ng/ml;其中男性中99%的人(n = 119)25 ( OH) D的浓度小于30 ng/ ml;女性中95%的人(n = 122)25( OH)D的浓度小于30 ng/ml。研究对象中83% (n =206)的人伴有股骨颈骨质疏松;86%的 人(n =214)伴有腰椎的骨质疏松。其中男性中82%的人(n =98)伴有股骨颈骨质疏松,84. 2%的人(n = 101)伴有腰椎的骨 质疏松。女性中84. 4%的人(n = 108)伴有股骨颈骨质疏松,88. 3%的人(n = 113)伴有腰椎的骨质疏松。在多变量的数据分 析里,校正了年龄、体重指数的差异后,发现25( OH) D与骨密度之间存在一定关系(见表3、4、5)。结论在中国上海健康中 老年人群中存在严重的维生素D不足和缺乏状况,维生素D的状态与骨密度可能存在正性相关,必须进一步进行大样本的 研究来探讨维生素D与骨质疏松症及骨折的关系。
英文摘要:
      Objective To investigate the correlation between vitamin D and bone mineral density (BMD). Methods A total of 248 middle-—ged and elder Shanghai residents,including 128 women and 128 men,aged between 40 and 90 years old,were randomly selected from participants of a population-based study. BMD of the whole body and serum 25—OH) D level were detected. The correlation between those was analyzed. Results The average age of all the subjects was 70. 03 ± 11. 44 years old, an average age of 70. 96 士 12. 22 years old in men and 69. 16 士 10. 62 years old in women. The total concentration of 25— OH) D in all the subjects was 13. 733 ±6. 894 ng/ml. The average concentration of 25—OH)D2 and 25 — OH) D3 in all subjects was 1. 672 士 1. 577 ng/ml and 12.057±6.631 ng/ ml,respectively. In men,the concentration of total 25— OH) D,25 — OH) D2,and 25 — OH) D3 was 14. 258 ±5. 557 ng/ml,1. 580 士 1. 548 ng/ml,and 12. 710 ±5. 440 ng/ml,respectively. The concentration in women was 13. 241 ±7. 937 ng/ml,1. 758 士 1. 604 ng/ml,and 11. 445 ±7. 550 ng/ml,respectively. Among all the subjects,83% (n =206) had femoral neck osteoporosis, and 86% ( n = 214) had lumbar osteoporosis. In men,82% ( n =98) had femoral neck osteoporosis,and 84.2% (n = 101) had lumbar osteoporosis. In women,84.4% (n = 108) had femoral neck osteoporosis,and
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