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| 分子信号通路在骨质疏松防治中的研究进展 |
| Research progress of the molecular signal pathway in the prevention and treatment of osteoporosis |
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| DOI： |
| 中文关键词: 分子信号通路 骨质疏松 骨代谢 |
| 英文关键词:Molecular signal pathway Osteoporosis Bone metabolish |
| 基金项目:四川省科技厅科技支撑计划（2011SZ0097) |
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| 中文摘要: |
| 大量骨质疏松的分子水平研究发现，骨代谢过程中存在受多种调节因子调控的信号通路，如OPG/RANKL/RANKL通 路、Wnt/P-^atenin通路、组织蛋白酶K通路和骨形成蛋白通路。通过研究上述分子信号通路，明确各信号通路中的重要靶点， 通过抑制或促进各靶点蛋白的合成和分泌，达到抑制骨吸收和促进骨形成的目的，从而对骨质疏松症的防治开辟新的方向。 |
| 英文摘要: |
| Abundant researches of osteoporosis at molecular level reveal that the bone metabolism is regulated by various molecular signal pathways，including OPG/RANKL RANKL pathway，Wn^ p-catenin pathway，Cathepsin K pathway，and BMP pathway. Through the researches of these signal pathways，we can identify the important target in each signal pathway. By inhibiting or promoting the synthesis and secretion of each target protein， we can inhibit bone resorption and promot bone formation， finally developing a new strategy in the prevention and treatment of osteoporosis. |
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