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| P53基因在类风湿关节炎骨代谢中的作用 |
| Function of P53 gene in the bone metabolism in rheumatoid arthritis |
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| DOI： |
| 中文关键词: 类风湿关节炎 P53基因 骨代谢 |
| 英文关键词:Rheumatoid arthritis P53 gene Bone metabolism |
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| 中文摘要: |
| 类风湿关节炎(rheumatoid arthritis .RA)作为一种自身免疫性疾病,其病理表现为血管翳侵袭性增生破坏滑膜及骨质. 与肿瘤的异常增生类似，引起人们对RA发病过程是否有癌基因参与的设想。而骨代谢异常贯穿于RA的整个病程,可以表 现为局部骨侵蚀、骨质疏松症(osteoporosis .OP)甚至病理性骨折。p53基因作为发现较早，分布最广的抑癌基因之一，在自身 免疫性疾病中的作用也日益受到重视。本文就p53在RA病程及RA骨代谢中可能的作用及机制进行阐述,并提出目前可能 存在的一些问题，希望对进一步的研究起到一定的提示作用。 |
| 英文摘要: |
| Rheumatoid arthritis (RA) is a kind of autoimmune diseases，with the pathological manifestation of invasive hyperplasia of pannus destroying the synovial membrane and the bone，which is similar to the pathologic hyperplasia in tumors. Now more attention has been paid to the possible involvement of oncogenes in RA. The disorder of bone metabolism happens during the whole course of RA，and it could present as local bone erosion，osteoporosis (OP)，or even pathological fractures. However，p53 gene， the oncogene with early discovery and wild distribution， plays a more and more important role in the autoimmune diseases. In this article，we illustrate the effect and mechanism of p53 in the RA and bone metabolism. We also point out some existed problems， hoping to be useful for the future researches. |
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