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| 维生素D缺乏相关性疾病研究进展 |
| Research progress in vitamin D deficiency-related diseases |
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| DOI： |
| 中文关键词: 维生素D缺乏 疾病 研究进展 |
| 英文关键词:Vitamin D deficiency Disease Research progress |
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| 中文摘要: |
| 维生素D是人体必需的一种脂溶性维生素.它通过维生素D受体发挥其主要作用。近10年人们对于维生素D的关注 度越来越高。根据流行病学调查，目前全球近10彳乙人处于维生素D不足或缺乏状态，我国人群维生素D不足现象也较为普 遍。由于1,254羟维生素D半衰期非常短，最近维生素D水平巳用血清25-羟维生素D水平来描述。多种证据表明.维生素D 缺乏不仅造成骨骼疾病(包括营养性徇偻病、软骨病、骨质疏松），还与多种骨骼外疾病密切相关，包括全因死亡率、心血管疾 病及心血管病死亡率、代谢综合征（肥胖、糖耐量减低/糖尿病、脂代谢紊乱、高血压）、恶性肿瘤、感染、过敏性疾病及哮喘、精 神及神经疾病、自身免疫性疾病、慢性肾病等。虽然使用维生素D治疗骨骼疾病巳经得到广泛认可，但是治疗骨骼外疾病的 疗效及远期效果还不明确。维生素D缺乏巳成为全世界的公共健康问题。本文综述了近年来对维生素D缺乏相关性疾病的 研究进展。 |
| 英文摘要: |
| As an essential fat-soluble vitamin in human body，the main function of vitamin D is mediated by vitamin D receptor. In the past decade，vitamin D has drawn more and more attention. According to epidemiological survey，there are almost one billion people under the state of vitamin D insufficiency or deficiency all over the world. And this phenomenon is very common in China. Because of the short half-life of vitamin D，more recently，the level of serum 25 -hydroxyvitamin D has been used to describe the level of vitamin D. Several lines of evidence indicate that the vitamin D deficiency is associated with not only skeletal disorders (including nutritional rickets， osteomalacla， and osteoporosis)， but also non-skeletal disorders， such as mortality rate， cardiovascular disorders and mortality，metabolic syndrome (including obesity，IGT/diabetes mellitus，lipid metabolism disorders， and hypertension) ， cancer， infection， allergy and asthma， neurological and mental diseases， autoimmune diseases， and chronic kidney diseases. Although the vitamin D treatment of skeletal disorders has been widely recognized，the efficacy and long-term effect on non-skeletal disorders is not clear. Vitamin D deficiency has become a worldwide public health problem. This article reviews the research progress in vitamin D deficiency related diseases in recent years. |
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