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| 依降钙素对绝经后骨质疏松女性腰椎退行性疾病治疗研究的观察 |
| Observation of elcatonin in the treatment of the lumbar degenerative diseases in postmenopausal women with osteoporosis |
| 投稿时间：2013-09-17 |
| DOI： |
| 中文关键词: 依降钙素 骨质疏松症 绝经后女性 腰椎退行性疾病 |
| 英文关键词:Elcatonin Osteoporosis Postmenopausal women Lumbar degenerative disease |
| 基金项目: |
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| 中文摘要: |
| 目的：探索依降钙素联合钙剂、维生素D对于绝经后骨质疏松的患者腰椎融合术后发生椎弓根螺钉松动、拔出现象的影响。方法观察40位年龄在55～70岁[（62.5±4.5）岁]之间患中度以上骨质疏松的绝经后老年女性（T＜-2.5），因腰椎退行性疾病接受腰椎后路减压融合术后，植入8颗椎弓根螺钉的患者，随机平均分为两组，第1组患者术后给予口服钙尔奇D片2片/日（每片含碳酸钙1.5 g及维生素D3125iu）及肌注依降钙素20单位/周，第2组患者给予口服钙尔奇D片2片/日。随访12个月，通过数字化平片、320排螺旋CT及手术取出内固定等方法观察两组患者椎弓根螺钉松动的发生率。结果通过统计学的方法分析后表明，两组患者的椎弓根螺钉松动、拔出的概率是不同的，经过进一步的分析发现接受依降钙素及补钙和维生素D治疗组的患者椎弓根螺钉发生松动的概率小于单纯接受补钙及维生素D治疗组。结论降钙素联合补钙和维生素D治疗可以减少绝经后骨质疏松女性椎弓根螺钉松动的发生率，其效果优于单纯补钙和维生素D治疗。 |
| 英文摘要: |
| Objective To investigate the efficacy of the combination of elcatonin, calcium, and vitamin D on the loosening and pull out of the pedicle screw after instrumented lumbar posterolateral fusion in postmenopausal women with osteoporosis.Methods Forty postmenopausal patients with moderate osteoporosis, aging from 55 to 70 years old, with an average age of 62.5 ±4.5 years old, were selected and observed.After the posterior lumbar decompression and fusion surgery because of lumbar degenerative disease, patients with the implantation of 8 pedical screws were divided into 2 groups with a ratio of 1∶1.Patients in the first gropu were treated with an oral medication of 2 tablets of Caltrate D per day ( each tablet contains 1.5g calcium carbonate and 125IU vitamin D3 ) and an intramuscular injection of 20 unit elcatonin per week.Patients in the second group were given an oral medication of 2 tablets of Caltrate D per day only.During the whole 12-month follow-up, the incidence of pedicle screw loosening was observed in 2 groups through digital flat sheet, 320-slice spiral CT, and surgical removal of implants.Results After statistical analysis, the results showed the incidence of the pedicle screw loose and pull out between 2 groups was significantly different. Further analysis revealed that the incidence of the pedicle screw loosening in patients treated with elcatonin, calcium, and vitamin D was lower than that in patients treated with calcium and vitamin D.Conclusion The combination of calcitonin, calcium, and vitamin D can reduce the incidence of the pedicle screw loosening in postmenopausal women with osteoporosis, and its effect is better than that in single treatment with calcium and vitamin D. |
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