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| 女性护骨素和转化生长因子-β水平对骨转换率的影响 |
| Effect of osteoprotegerin and transforming growth factor-βon bone turnover rate in women |
| 投稿时间：2013-09-25 |
| DOI： |
| 中文关键词: 护骨素 转化生长因子-β 骨转换指标 女性 |
| 英文关键词:Osteoprotegerin Transforming growth factor-β Bone turnover markers Women |
| 基金项目: |
| 作者 | 单位 | E-mail | | 钟如意 | 湖南省浏阳市人民医院内分泌科,湖南浏阳,410300 | | | 伍西羽 | 中南大学代谢内分泌研究所,湘雅二医院内分泌科,长沙 410011 | wuxiyu640@sohu.com | | 陈胜 | 湖南省浏阳市人民医院内分泌科,湖南浏阳,410300 | | | 李妙 | 湖南省浏阳市人民医院内分泌科,湖南浏阳,410300 | | | 伍贤平 | 中南大学代谢内分泌研究所,湘雅二医院内分泌科,长沙 410011 | | | 廖二元 | 中南大学代谢内分泌研究所,湘雅二医院内分泌科,长沙 410011 | |
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| 中文摘要: |
| 目的：了解女性护骨素（ OPG）和转化生长因子-β（ TGF-β）与骨转换指标的关系及其对骨转换指标的影响。方法研究长沙地区691名健康女性（年龄20～80岁）的血清OPG、TGF-β1和TGF-β2，以及血清骨特异性碱性磷酸酶（ BAP）、骨钙素（OC）、血清I型胶原N-末端肽（sNTX）、血清I型胶原C-末端肽（sCTX）、尿NTX （uNTX）、尿CTX （uCTX）和尿脱氧吡啶酚（ uDPD），并分析这些细胞因子与各种骨转换指标之间的关系。结果血清OPG和TGF-β2与血清BAP、OC、uNTX、uCTX和uDPD呈显著正相关（r＝0.145～0.397， P均＝0.000），血清TGF-β1与BAP、OC、sCTX、uNTX和uCTX呈显著负相关（r＝-0.114～-0.286，P均＝0.004～0.000）。调整年龄和BMI之后，它们之间的偏相关系数多数仍然有意义。多元线性回归分析显示，OPG和TGF-β2对BAP、uNTX和uCTX是一个正性决定因素，可分别解释这些指标0.6％～16.6％的变异。 TGF-β1对BAP、OC、和uCTX是一个负性决定因素，可以分别解释这些指标变异的0.7％～7.3％。结论本研究揭示了女性OPG和TGF-β与骨转换指标的关系，提示循环中的OPG和TGF-β是骨转换速率的重要决定因素。 |
| 英文摘要: |
| Objective To explore the relationship among osteoprotegerin ( OPG) , transforming growth factor-β( TGF-β) , and bone turnover markers, and to investigate their effect on bone turnover markers.Methods Cross-sectional study was conducted in 691 healthy women in Changsha, aging from 20 to 80 years old.The serum levels of OPG, TGF-β1 , TGF-β2 , serum bone-specific alkaline phosphatase ( BAP) , osteocalcin ( OC) , serum cross-linked N-terminal telopeptides of type I collagen ( sNTX) , and serum cross-linked C-terminal telopeptides of type I collagen ( sCTX) were detected.Simultaneously, the levels of urinary cross-linked N-terminal telopeptides of type I collagen (uNTX), urinary cross-linked C-terminal telopeptides of type I collagen (uCTX), and urinary deoxypyridinoline ( uDPD) were also detected.The relationship between these cytokines and the bone turnover markers was analyzed.Results The serum OPG and TGF-β2 were significantly positively correlated with serum BAP, OC, uNTX, uCTX, and uDPD (r=0.145-0.397, all P=0.000).The serum TGF-β1was significantly negatively correlated with BAP, OC, sCTX, uNTX, and uCTX (r =-0.114 -0.286, all P =0.004 -0.000).After adjusting age and BMI, the significance of partial correlation coefficients also existed. Multivariate linear regression analysis indicated that OPG and TGF-β2 were positive determinants to BAP, uNTX, and uCTX, explaining 0.6% -16.6% variance of these markers, respectively.TGF-β1 was a negative determinant to BAP, OC, and uCTX, explaining 0.7%-7.3%variance of these markers, respectively.Conclusion The relationship among OPG, TGF-β, and bone turnover markers in females are revealed in this study, indicating that OPG and TGF-βin circulation are important determinants to the bone turnover rate. |
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