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| 甲状旁腺激素（1-34）与唑来膦酸联合治疗对骨质疏松大鼠骨折愈合的影响 |
| Effect of the combination treatment with human parathyroid hormone (1-34) and zoledronic acid on fracture healing in osteoporotic rats |
| 投稿时间：2013-05-26 |
| DOI： |
| 中文关键词: 双膦酸盐 骨折愈合 骨质疏松 甲状旁腺激素 |
| 英文关键词:Bisphosphonates Fracture healing Osteoporosis Parathyroid hormone |
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| 中文摘要: |
| 目的：探讨唑来膦酸（ZA）与甲状旁腺激素（PTH）的联合应用对去势大鼠骨折愈合的影响。方法对双侧卵巢摘除术12周后的大鼠行单侧胫骨水平骨切开术，并以髓内钉进行固定。所有大鼠在行骨折造模术后，随机接受赋形剂、ZA、PTH与ZA＋PTH治疗。在治疗4或8周后，收集胫骨标本进行micro-CT、组织学及生物力学测试。结果与对照组相比，所有药物干预方法都促进了骨痂形成、增加了骨痂强度；ZA＋PTH组在相对骨体积（BV/TV）、骨小梁粗度和生物力学上表现出了最强的促进作用。结论ZA与PTH联合应用对去势大鼠的骨折愈合有累加作用。 |
| 英文摘要: |
| Objective To investigate the effect of combined treatment with zoledronic acid ( ZA ) and parathyroid hormone ( PTH) on fracture healing in OVX rats.Methods Rats in this study received bilateral ovariectomy.Twelve weeks later, the unilateral transverse osteotomy on the tibia was performed in rats.Then, the tibia was fixed with intramedullary nail.After the establishement of fracture model, the rats were then randomly treated with vehicle, ZA (1.5μg/kg weekly), PTH (60 μg/kg, three times a week) , or ZA plus PTH.After 4-or 8-week treatment, the fractured tibia was collected.And micro-CT, histology, and biomechanical test were performed.Results Compared with that in control group, the formation and strength of the callus increased in all treatment groups. The best promotion of relative bone volume ( BV/TV ) , the trabecular thickness, and biomechanical strength was observed in ZA+PTH group.Conclusion The combination of ZA and PTH has a cumulative effect on fracture healing in OVX rats. |
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