中国骨质疏松杂志

基于社区的肥胖与原发性骨质疏松症的关联性研究

The study of the correlation between obesity and primary osteoporosis in community

投稿时间：2013-05-10

DOI：

英文关键词:Obesity Primary osteoporosis Community

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作者	单位	E-mail
孙勇	新疆医科大学第一附属医院,乌鲁木齐,830054	sunyong718@sina.com
周晓芹	新疆医科大学校医院,乌鲁木齐,830011
廖燚	新疆克拉玛依市中心医院,新疆克拉玛依,834000
王淑霞	新疆医科大学第一附属医院,乌鲁木齐,830054
张嫣	新疆医科大学第一附属医院,乌鲁木齐,830054

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中文摘要:

目的：研究肥胖与原发性骨质疏松症的关联性。方法基于社区多级整群抽样的方法，获得2498例18岁以上居民的相关信息，通过HOLOGIC双能X线骨密度仪测定骨密度，通过分层及多因素logistic回归分析，对肥胖与原发性骨质疏松症的关联性进行研究。结果按照性别分层，男性人群中结果显示肥胖和原发性骨质疏松症呈负关联（χMH2＝26.845，P＜0.001），同时也可以看到Ⅱ度肥胖者的原发性骨质疏松症患病率要高于Ⅰ度肥胖者（11.1％＞6.6％）；女性人群中肥胖和原发性骨质疏松症的关联无统计学意义（χMH2＝2.007，P＝0.157）；如不分层，资料显示人群肥胖和原发性骨质疏松症呈负关联（χMH2＝7.016，P＝0.008）。按照年龄分层后，各年龄段（除age≥70组）均显示肥胖和原发性骨质疏松症呈负关联（χMH 2值依次为4.152、15.306、10.212、18.499、3.341，P值依次为0.042、＜0.001、0.001、＜0.001、0.068）。通过多因素logistic回归分析，调整性别、年龄后，结果显示肥胖和原发性骨质疏松症呈负关联（OR＝0.703，OR的95％C．I．为0.620～0.799）。结论骨质疏松症与肥胖有密切联系，体重管理在预防骨质疏松方面的作用是个公共健康问题，值得广泛关注。

英文摘要:

Objective To study the correlation between obesity and primary osteoporosis.Methods Adopting the multi-stage cluster sampling method based on community, the information of 2498 residents elder than 18 years old was obtained.The bone mineral density ( BMD) was measured using the HOLOGIC dual energy X-ray absorptiometry.The results were analyzed using stratification analysis and the multivariate logistic regression analysis, in order to investigate the correlation between obesity and primary osteoporosis.Results When stratified by sex, a negative correlation between obesity and primary osteoporosis was observed in males (χ2MH =26.845, P<0.001).Simultaneously, the prevalence of primary osteoporosis in subjects with II degree obese was higher than that in I degree obese (11.1% >6.6%).In females, no significant association between obesity and primary osteoporosis was observed (χ2MH =2.007, P=0.157).Without the stratification of gender, the data showed a negative correlation between obesity and primary osteoporosis (χ2MH =7.016,P=0.008).When stratified by age, each period ( except the age group over 70) showed that obesity and primary osteoporosis was negatively associated (χ2MH =4.152, 15.306, 10.212, 18.499, and 3.341, respectively; and P was 0.042, 0.001, 0.001, <0.001, and 0.068, respectively).Through the multivariate logistic regression analysis, after adjusting the gender and age, the results showed that obesity and primary osteoporosis was negatively associated (OR =0.703, 95%CI: 0.620 -0.799).Conclusion Osteoporosis is closely associated with obesity.Weight management is a public health problem in the prevention of osteoporosis, which should be paid more attention.

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