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| 左卡尼汀对肥胖骨质疏松椎体压缩骨折患者术后恢复 及脂代谢影响 |
| Effect of L-carnitine on postoperative recovery and lipid metabolism in obese patients with osteoporotic vertebral compression fractures |
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| DOI： |
| 中文关键词: 骨质疏松 骨密度 左卡尼汀 脂肪因子 |
| 英文关键词: |
| 基金项目: |
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| 摘要点击次数: 1168 |
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| 中文摘要: |
| 目的研究左卡尼汀对肥胖骨质疏松椎体压缩骨折患者术后恢复及脂代谢影响。方法选择肥胖合并骨质疏松椎体 压缩骨折椎体后凸成形术后病人84例，随机分为A组与B组。A组采取钙尔奇D +阿仑膦酸钠治疗，B组在此基础上加用左 卡尼汀治疗。治疗前及经治疗后分别检查两组患者的骨密度、生化指标、血脂及脂肪因子。结果A组治疗后L144骨密度 及全髋关节骨密度较治疗前显著改善(P <0.05)，B组L144骨密度及股骨颈骨密度、全髋关节骨密度治疗后较治疗前均有 显著性改善(P <0. 05)。治疗后B组股骨颈骨密度、全髋关节骨密度较A组有显著性差异（P <0. 05)。A组治疗后CTX4、 BGP较治疗前显著改善(P < 0. 05)。B组治疗后较治疗前CTX4、BGP均有显著性改善（P < 0. 05)。治疗后B组CTX~L、BGP 较A组具有显著性差异（P <0. 05)。B组治疗后较治疗前TG、HDL、LDL均有显著性改善（P <0. 05 )。治疗后B组TG、HDL、 LDL较A组具有显著性差异（P <0. 05)。A组治疗后Chemerin较治疗前有显著下降（P <0. 05)。B组治疗后较治疗前 Chemerin、Visfatin、Vaspin 均有显著性改善（P < 0. 05)。治疗后 B 组 Chemerin、Visfatin、Vaspin 较 A 组具有显著性差异（P < 0.05)。CTX-L、BGP 与 Chemerin、Visfatin、Vaspin 呈显著负相关（P < 0. 05)。 ALP 与 Chemerin、Visfatin、Vaspin 未见显著相关 性(P >0. 05)。结论肥胖所致脂肪因子代谢紊乱可影响骨质疏松恢复，左卡尼汀可纠正改善脂肪因子水平，有助于骨质疏 松性椎体骨折骨密度恢复。 |
| 英文摘要: |
| Objective To investigate the effect of L-carnitine on postoperative recovery and lipid metabolism in obese patients with osteoporotic vertebral compression fractures. Methods Eighty--our obese patients with osteoporosis vertebral compression fractures after kyphoplasty were selected. All the patients were randomly divided into group A and group B. Patients in group A were treated with Caltrate D + alendronate， and on this basis， patients in group B were treated with L-carnitine therapy additionally. Bone mineral density (BMD)，biochemical markers，and lipids and adipokines in both groups were detected before and after the treatment. Results After the treatment， BMD of L1-L4 and the total hip in Group A improved significantly compared with that before the treatment (P < 0. 05). BMD of L1-L4，the femoral neck，and the total hip in group B all improved significantly than that before the treatment (P < 0. 05). After the treatment，BMD of the femoral neck and the total hip in Group B was significantly different with that in group A (P <0. 05). The CTX4 and BGP level in group A and group B improved significantly after the treatment (P < 0. 05)，and the difference between the two groups was significant (P < 0. 05). The levels of TG，HDL，and LDL in group B improved significantly after the treatment (P <0. 05)，and the difference of TG，HDL，and LDL between group A and group B was significant (P < 0. 05). The Chemerin level in group A after the treatment decreased significantly (P < 0. 05)，while the levels of Chemerin，Visfatin，and Vaspin in group B improved significantly after the treatment (P < 0. 05). And the difference of Chemerin，Visfatin，and Vaspin between group B and group A was significant (P <0. 05). The levels of |
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