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| MITF在破骨细胞中的作用研究进展 |
| Research progress in the function study of MITF in osteoclasts |
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| DOI： |
| 中文关键词: 小眼畸形相关转录因子 抗酒石酸酸性磷酸酶 组织蛋白酶K 破骨细胞相关受体 氯离子通道-7 骨硬化相关跨膜蛋 白4 E^钙粘蛋白 |
| 英文关键词:MITF TRAP Cathepsin K OSCAR Clcn7 Ostm1 E-cadherin |
| 基金项目:国家自然科学基金资助课题（No：81203003) |
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| 中文摘要: |
| MITF( microphthalmia-associated transcription factor . MITF)是小眼畸形相关转录因子，它在破骨细胞中的作用成为近几年 骨科领域的研究热点。不断有研究证实，MITF调节破骨细胞中众多功能相关基因的转录，包括抗酒石酸酸性磷酸酶(tartrate- resistant acid phosphatase .TRAP)，组织蛋白酶 K( Cathepsin K)，破骨细胞相关受体(osteoclastassociated receptor .OSCAR)，氣离 子通道 ~7( chloride channel -7，Clcn7)，骨硬化相关跨膜蛋白!( osteopetrosis -associated transmembrane protein 1，Ostm1)和 E-钙粘 蛋白（E-cadherin)等。无论在MITFmi/mi突变的小鼠模型还是来源于MITFmi/mi突变的小鼠体外培养的破骨样细胞中，我们都能 检测到上述与破骨细胞众多功能相关基因的表达都会受到明显抑制，导致破骨细胞功能异常，小鼠患有严重的骨硬化病。因 为小鼠和人类的MITF基因序列具有很高的同源性，所以理解MITF调控系统对小鼠破骨细胞的作用也将有助于我们阐明妇 女绝经后的骨质疏松症、骨硬化病或者发生在多发性骨髓瘤患者身上的溶骨性骨质破坏和高钙血症等人类疾病的分子作用 机制。现就MITF在破骨细胞中的作用做一综述。 |
| 英文摘要: |
| In recent years，the function of microphthalmia-associated transcription factor (MITF) in osteoclasts has become a hot field in orthopedics. Various studies have confirmed that MITF can regulate the transcription of numerous osteoclast functionally related genes， including tartrate resistant acid phosphatase ( TRAP)， Cathepsin K， osteoclast-associated receptor ( OSCAR)， chloride channel^? (Clcn7)，osteoporosis -associated transmembrane protein 1 (Ostm1)，and E-cadherin. Not only in the MITFmi/mi mutant mouse model but also in osteoclast-like cells derived from mutant MITFmi/mi mice， the expression of these numerous osteoclast functionally related genes was significantly inhibited， resulting in abnormal osteoclast function， leading to severe osteoporosis in mice. The MITF gene sequences in mouse and human are highly homologous. So，understanding the regulatory system of MITF in mouse osteoclasts provides us an attractive model， which will help us to elucidate the molecular mechanism of human disorders， including osteoporosis in postmenopausal women， osteopetrosis， the osteolytic bone destruction， and hypercalcemia in patients with multiple myeloma. This article reviews the regulatory effect of MITF in osteoclasts. |
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