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| BMP2信号通路与经典Wnt信号通路及相互交联对成 骨分化的调控 |
| The regulation of osteogenic differentiation by BMP2 and the canonical Wnt signaling pathway and the crosstalk between them |
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| DOI： |
| 中文关键词: BMP2信号通路经典Wnt信号通路成骨分化相互作用 |
| 英文关键词:BMP2 signaling pathway Canonical Wnt signaling pathway Osteogenic differentiation Crosstalk |
| 基金项目:河北省自然科学基金资助项目（H2013209255) |
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| 中文摘要: |
| 在以间充质干细胞为代表的具有成骨分化潜能的细胞中，多条信号传导通路及其构成的动态调控网络参与调控其成 骨分化过程。其中BMP2和经典Wnt信号通路在此过程中的作用日益受到关注。国内外研究表明，BMP2和经典Wnt信号通 路在调控靶细胞成骨分化过程中伴有彼此通路中的关键分子的表达水平和功能活性的改变，并在一定条件下表现出对成骨 分化特异性标志物的协同和拮抗调控。成骨增殖分化过程是一个动态过程，在成骨分化的不同阶段，分子通路的作用不同， 相互之间的调节也动态变化的，研究BMP2和经典Wnt信号通路在成骨分化过程中的相互调节作用，对于指导治疗骨质疏松 和骨折有重要的作用，本文就BMP2和经典Wnt信号通路对靶细胞成骨分化的调控作用以及在此过程中两条信号通路之间的 交联作一简要综述。 |
| 英文摘要: |
| The osteogenic differentiation process in mesenchymal stem cells and other lineages that are capable of differentiating into osteoblasts，is regulated by several signal transduction pathways and the dynamic regulatory networks consisted of them. In this process，more and more attention has been paid to the role of BMP2 signaling pathway and canonical Wnt signaling pathway. Previous studies have shown that BMP2 and canonical Wnt signaling pathway can regulate the osteogenic differentiation process in target cells，during which the expression level and functional activity of key molecules in one signaling pathway are regulated by the other. Moreover， they also exhibit cooperative or antagonize interaction on the regulation of osteogenic differentiation biomarkers. This paper briefly summarizes the role of BMP2 and canonical Wnt signaling pathway in regulating osteogenic differentiation and the crosstalk between the two signaling pathways in this process. |
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