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| 青少年特发性脊柱侧凸与骨密度 |
| Adolescent idiopathic scoliosis and bone mineral density |
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| DOI： |
| 中文关键词: 青少年特发性脊柱侧凸 发病机制 骨密度 骨微观结构 基因多态性 信号传导通路 |
| 英文关键词:Adolescent idiopathic scoliosis Pathogenesis Bone mineral density Bone microstructure Gene polymorphism Signal transduction pathway |
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| 中文摘要: |
| 青少年特发性脊柱侧凸（Adolescent Idiopathic Scoliosis，AIS)是一种原因不明的发生于青春期的结构性脊柱侧凸，与基 因多态性、生长发育等多因素发病机制可能有关。巳有很多研究发现AIS患者全身多处骨密度降低，但具体机制阐释不多。 本文拟从骨微观结构及生物力学、基因多态性、信号传导通路三方面对AIS疾病与低骨密度的相互关系进行深人探讨。增强 骨密度可能对改善AIS患者的治疗有重要意义。 |
| 英文摘要: |
| Adolescent idiopathic scoliosis (AIS) is an unexplained occurrence of structural scoliosis in adolescence. Multiple factors，such as gene polymorphism，growth and development，etc.，may be related to the pathogenesis of this disease. Many studies have found that patients with AIS may have low bone mineral density (BMD) in the whole body，but the mechanism still remains unknown. This paper reviews the relationship between low BMD and AIS in three aspects，including bone microstructure and biomechanics，gene polymorphism，and signal transduction pathway. Improving BMD may be benefit for the treatment of AIS. |
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