|
| 绝经后骨质疏松症肾阴虚证关联基因CLCF1 mRNA的表达研究 |
| Study of the expression of CLCF1 mRNA in postmenopausal osteoporosis patients with the kidney Yin deficiency |
| |
| DOI：10.3969/j.issn.1006-7108.2014.06.007 |
| 中文关键词: 肾阴虚证 绝经后骨质疏松症 CLCF1 基因表达 |
| 英文关键词:Kidney Yin deficiency Postmenopausal osteoporosis Cardiotrophin-like cytokine factor 1 (CLCF1) Gene expression |
| 基金项目:国家自然科学基金资助项目（81173280）；福建省卫生厅医学创新课题（2011-CX-30）；福建省教育厅科科技项目（JA11133）；福建省科技厅省属公益类科研院所自主选题项目（2013fjzyyk-4） |
|
| 摘要点击次数: 1138 |
| 全文下载次数: 1046 |
| 中文摘要: |
| 目的 研究绝经后骨质疏松症肾阴虚证差异表达基因CLCF1、ASB1和PROK2 的mRNA表达水平。方法 随机选择绝经后骨质疏松症患者，中医辨证肾阴虚证组30例，27例健康绝经后妇女为对照组，RT-PCR法检测外周血CLCF1、ASB1和PROK2 mRNA的表达。 结果 肾阴虚组CLCF1 mRNA表达水平明显低于对照组（Z=-2.621，P=0.009）；肾阴虚组ASB1 mRNA表达与对照组比较，有降低趋势，但差异无统计学意义；与健康对照组比较，肾阴虚组PROK mRNA表达差异无统计学意义。 结论 骨质疏松症肾阴虚证与CLCF1 mRNA表达下调关联。 |
| 英文摘要: |
| Objective To investigate the mRNA expression of CLCF1, ASB1, and PROK2 in postmenopausal osteoporosis patients with the kidney Yin deficiency. Methods Patients with postmenopausal osteoporosis were randomly selected. Thirty patients were selected as the kidney Yin deficiency syndrome group, and another 27 patients with normal bone mineral density (BMD) were selected as control group. The mRNA expression of CLCF1, ASB1, and PROK2 in the peripheral blood was detected using real-time RT-PCR. Results The expression of CLCF1 mRNA in the kidney Yin deficiency group was significantly lower than that in the control group (Z=-2.621, P=0.009). Compared with that in the control group, the expression of ASB1 mRNA in the kidney Yin deficiency group showed a declining tendency, but no significant difference was observed. Compared with that in control group, no significant difference of PROK mRNA expression in the kidney Yin deficiency group was observed. Conclusion Down-regulation of CLCF1 mRNA expression may have correlation with the postmenopausal osteoporosis with the kidney Yin deficiency. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |