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| 25-OH-D2、25-OH-D3与股骨颈骨密度的相关性研究 |
| Correlation study between 25-OH-D2, 25-OH-D3, and the bone mineral density of the femoral neck |
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| DOI：10.3969/j.issn.1006-7108.2014.06.008 |
| 中文关键词: 股骨颈骨密度 25-OH-D2 25-OH-D3 相关性 |
| 英文关键词:Femoral neck BMD 25-(OH)D2 25-(OH)D3 Correlation |
| 基金项目:贵州省人民医院-贵州省科学技术厅联合基金课题（黔科合LS字[2012]047号） |
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| 中文摘要: |
| 目的 研究人体内25羟维生素D2(25-OH-D2）、25羟维生素D3 (25-OH-D3)含量与股骨颈骨密度的相关性。方法 利用双能X线骨密度测量法检测205例患者股骨颈骨密度，同时用高效液相色谱法检测其血清中25-OH-D2及25-OH-D3的含量，并根据维生素D(VitD)含量分析VitD与骨密度的关系。结果 人体内VitD(25-OH-D2+25-OH-D3)含量与50岁以下者的股骨颈骨矿含量无相关性（P＞0.05），与50岁以上者呈正向直线相关（P＜0.05或P＜0.01），男女性别均一致。结论 对于50岁以上者，随着年龄的增长，其体内血清VitD的含量降低很可能会导致其股骨颈骨矿含量下降。 |
| 英文摘要: |
| Objective To investigate the correlation between the content of the 25-hydroxyvitamin D2 (25-(OH)D2) and 25-hydroxyvitamin (25-(OH)D3) and the bone mineral density of the femoral neck (femoral neck BMD). Methods The femoral neck BMD of 205 patients was detected using dual energy X-ray absorptiometry. The serum levels of 25-(OH)D2 and 25-(OH)D3 were determined using high performance liquid chromatography. The correlation between Vitamin D (Vit D) content and the femoral neck BMD was analyzed. Results In patients younger than 50 years old, no correlation between the VitD (25-(OH)D2 and 25-(OH)D3) content and the femoral neck BMD was observed (P>0.05). But in patients elder than 50 years old, a positive linear correlation was observed (P<0.05 or P<0.01). This existed both in men and women. Conclusion In patients elder than 50 years old, the serum Vit D level decreases along with the increase of age, which may cause a decline in the femoral neck BMD. |
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