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| 孕妇维生素D缺乏及其对胎儿的影响 |
| Vitamin D deficiency in pregnant women and its effect on the newborns |
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| DOI：10.3969/j.issn.1006-7108.2014.06.011 |
| 中文关键词: 女性 妊娠 维生素D缺乏 出生大小 |
| 英文关键词:Women Pregnancy Vitamin D deficiency Birth size |
| 基金项目: |
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| 中文摘要: |
| 目的 维生素D缺乏累及的人群非常广泛，而且与多种疾病的发生有关，特别是孕妇维生素D缺乏还可能影响到胎儿的健康。目前关于我国女性维生素D的资料报道很少。本研究的目的是了解健康孕妇（孕15~21w）以及同龄未孕对照组妇女维生素D水平以及孕妇维生素D水平对新生儿出生大小的影响。方法 本文随机选取单胎妊娠孕妇63例和同龄对照妇女35例，用酶联免疫的方法测定血中25-羟维生素D水平。结果 显示99%的检测病例25-羟维生素D水平低于正常值(≥75 nmol/L)，有近93%的妇女为维生素D缺乏(＜50 nmol/L)。孕妇25-羟维生素D水平（28.40±9.19 noml/L）明显低于对照组妇女（38.46±10.77 noml/L; P＜0.001），两组维生素D缺乏的比率分别为孕妇96.8%，对照组85.7%，但重度维生素D缺乏的病例孕妇组接近半数，而对照组为零。新生儿身长与孕妇25-羟维生素D水平成显著正相关（r=0.323; P＜0.01。结论 我国北方女性特别是孕妇是维生素Ｄ缺乏患病的高危人群，而且孕妇维生素Ｄ缺乏可能会影响到胎儿的生长发育。应该积极采用有效的措施防治维生素Ｄ的缺乏，从而减少维生素Ｄ缺乏对健康的影响对提高人口质量将具有重要的意义。 |
| 英文摘要: |
| Objective Vitamin D deficiency is very common and associated with various diseases, especially in pregnant women, which may affect the fetal health. At present, little is known about the vitamin D status in Chinese women. The aim of this study was to investigate the vitamin D status in healthy pregnant women (15~21 weeks) and a group of age-matched non-pregnant control women, and to observe the effect of the vitamin D status on the size of the newborns. Methods Sixty-three pregnant women and 35 non-pregnant women were selected. The serum 25-hydroxyvitamin D (25-(OH)D) level was determined using enzyme-linked immunosorbent assay. Results The serum 25-(OH)D level in 99% subjects was lower than 75 nmol/L (normal range). And 93% subjects had 25-(OH)D deficiency (＜50 nmol/L). The serum 25-(OH)D level in pregnant women (28.40±9.19 nmol/L) was significantly lower than that in non-pregnant women (38.46±10.77 nmol/L; P＜0.001). The rate of vitamin D deficiency in pregnant women and non-pregnant women was 96.8% and 85.7%, respectively. Near half of the pregnant women had severe vitamin D deficiency, while none in the control group. The height of the newborns was significantly positively correlated with the maternal 25-(OH)D levels (r=0.323; P<0.01). Conclusion Women, especially the pregnant women in the northern part of China, are high risk population of vitamin D deficiency. Fetal development may be influenced by maternal vitamin D deficiency. Measures should be taken to prevent women from vitamin D deficiency in China, thus reducing the effect of vitamin D deficiency on the health of population. |
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