| Bisphosphonates are mainly used in the treatment of metabolic bone diseases, which is characterized by the pathological features of increased osteoclast activity, including Paget's bone diseases (Paget's disease), bone metastases, tumor-induced hypercalcemia, and osteoporosis. From the P-O-P structure in pyrophosphate to the P-C-P structure in the 3rd generation bisphosphonate, the anti-resorption effect enhances with the extension of the carbon linked side chains. Technetium [99Tc] methylenediphosphonate (99Tc-MDP), a kind of bisphosphonate, mainly constitutes the chelate formed by the reduced technetium [99Tc], after reacting with the stannous chloride, and the methylene bisphosphonate. It has a stable P-C-P bond, which can be absorbed by bone formation area and bone or cartilage tissues with inflammation. It can not only effectively reduce the blood immunomodulatory factors and inhibit pathological complexes producing, but also inhibit osteoclast activity and repair the broken bone in various national and international studies, which has caused much attention by osteoporosis researchers. This paper reviews the research progress of the effect of 99Tc-MDP on bone remodeling. |