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| 老年骨质疏松患者肌力与骨密度等指标的相关性研究及不同干预方法的疗效评价 |
| The correlation between muscle strength and bone mineral density and other indicators in senile patients with osteoporosis and the efficacy evaluation of different interventions |
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| DOI：10.3969/j.issn.1006.7108.2014.07.020 |
| 中文关键词: 骨质疏松 肌力 身体成分 骨密度 25( OH) D3 |
| 英文关键词:Osteoporosis Muscle strength Body composition BMD 25(OH) D3 |
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| 中文摘要: |
| 目的 明确肌力与身体成分、25 (OH)D3、骨密度之间的具体关系，探讨肌力训练联合骨质疏松基础治疗与单纯基础治疗在疗效上的差异。方法 选择老年骨质疏松症患者120例，分为A、B两组，A组患者予阿法骨化醇片治疗，B组患者在A 组治疗的基础上联合肌力训练，利用肌力检测装置，双能X线骨密度仪，ELISA试剂盒等检测A、B两组治疗前后仰卧推举，负重蹲起，负重屈肘，握力的最大肌力，脂肪含量、瘦体重等身体成分，血清25 ( OH) D3水平及L1~L4、左侧股骨颈的骨密度值。 结果A、B两组患者肌力与脂肪含量、体脂百分比呈负相关（-1 |
| 英文摘要: |
| Objective To investigate the correlation between muscle strength and body composition，25 (OH) D3，and BMD，and to explore the different efficacy between strength training associated with basic treatment of osteoporosis and basic treatment of osteoporosis alone. Methods A total of 120 senile patients with osteoporosis were selected. The patients were divided into two groups：Group A and Group B. Patients in Group A were treated with alfacalcidol tablets，while patients with Group B were treated with the strength training associated with alfacalcidol tablets. Before and after treatment，the maximum muscular strength of bench press，weight bearing squat，weight bearing elbow flexion，and grip were measured using a muscular strength detection device. The fat content，lean body mass，and the serum level of 25 (OH) D3 were also detected. The bone mineral density (BMD) of L1-L4 and the left femoral neck was detected using dual-energy X-ray absorptiometry. Results The muscle strength in both groups was negatively correlated with fat content and the percentage of body fat ( - 1 < r <0，P <0. 001)，while positively correlated with the lean body mass，the serum level of 25 (OH)D3，and BMD of L1-L4 and the left femoral neck (0 < r <1，P <0. 001). The serum level of 25 (OH) D3 and BMD after the treatment in both groups were higher than those before the treatment (P <0. 001). And the efficacy in Group B was better than that in Group A (P < 0. 05). Conclusion Muscle strength is negatively correlated with the fat content and the percentage of body fat，while positively correlated with the lean body mass，the serum level of 25 ( OH) D3，and BMD of L1-L4 and the left femoral neck. Alfacalcidol tablets is able to improve the serum level of 25 (OH) D3 and BMD. The strength training has the synergistic effect，and the body composition has little change before and after the treatment. |
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