| Objective To investigate the difference of the bone mineral density and bone metabolic markers between Uygur and Han postmenopausal women with type 2 diabetes, and to provide theoretical basis for the prevention and treatment of osteoporosis. Methods A total of 405 Uygur and Han postmenopausal women with type 2 diabetes, who were hospitalized in the Department of Endocrinology in our hospital from January 2008 to December 2013, were selected.They were divided into two groups according to their nationality.The changes of the serum levels of calcium, phosphorus, alkaline phosphatase, bone gla protein ( BGP) , and 25-hydroxy vitamin D3 were recorded and analyzed.The bone mineral density ( BMD ) was also detected.Results The serum calcium in Uygur patients was slightly lower than that in Han patients, but no significant difference was observed.There was significant difference of the serum phosphorus level between the two groups.The serum levels of alkaline phosphatase, 25-hydroxy vitamin D3 in Uygur patients were significant lower than those in Han patients (P<0.05).The serum BGP level in Uygur group was significant higher than that in Han group ( P<0.05 ) .According to the different duration of menopause, the proportion of patients with low bone mass was higher in Uygur group, and the incidence of osteoporosis in Uygur group was higher than that in Han group.The proportion of Han patients was significantly higher than that of Uygur patients in normal BMD group.BMD of the femoral neck, the greater trochanter, and the lumbar vertebrae in Uygur group was lower than that in Han group.BMD of the femoral neck and the lumbar vertebrae in Uygur patients decreased more significantly than that in Han patients, but there was no significant difference.Conclusion The bone metabolism in Uygur postmenopausal women with type 2 diabetes decreases more significantly than that in Han patients. |