| Osteoporosis is a major disease, which hazards human life and health.However, with characteristics of“four high and one low”, the incidence of postmenopausal osteoporosis is rising year by year, and the prevention research has attracted the concern of the medical field increasingly. Blood stasis is one of the important mechanisms in the pathogenesis of postmenopausal osteoporosis, and the changes in microvascular blood are the pathological basis of stasis.Angiogenesis plays an important role in physiological bone growth and bone remodeling, as well as in pathological bone diseases, and it can reflect the local bone regeneration process to some extent.Thus, angiogenesis is closely related to osteoporosis.Some blood-circulation-activating traditional Chinese drugs can stimulate angiogenesis directly or indirectly.Panax notoginseng saponins ( PNS ) has a unique pharmacological activity, which promotes angiogenesis in the treatment of ischemic diseases.The related research reports accumulate increasingly.But there is no related report nationally and internationally using PNS as a research object and angiogenesis as a therapeutic target to investigate the treatment of postmenopausal osteoporosis by promoting angiogenesis.This article aims to provide a new way to explore PNS in relieving postmenopausal osteoporosis by promoting angiogenesis, which could be refered for further in-depth mechanistic and clinical studies. |