| In the recent years, along with the in-depth study of diabetic osteoporosis, more and more attention has been paid to the medication choices in the treatment of type 2 diabetic osteoporosis.Incretin, metformin, and insulin secretagogues can inhibit bone resorption, promote bone synthesis, and induce the differentiation of bone marrow mesenchymal cells in many aspects, which may have positive effect on the type 2 diabetic osteoporosis.The effect of insulin on osteoporosis is still controversial, but the continuous insulin therapy at the early stage could control and delay the occurrence and development of diabetic osteoporosis. The thiazolidinediones can significantly increase the incidence of fractures in women with type 2 diabetes mellitus. |