| Recent reports have described osteonecrosis of the jaw bones as a potentially serious complication related to the long-term use of bisphosphonates, and the incidence ranges from 0 to 28%.The bisphosphonate-related osteonecrosis of the jaws ( BRONJ) is characterized by ischemic osteonecrosis and bone exposure, and is accompanied with sever pain, fistula, and pathological fractures, which immensely influences the quality of patients ’ life and the related treatment.The pathogenesis of BRONJ is complex and still remains uncertain, which may include the pharmacological action of drugs, trauma, infection, and the susceptibility casued by possible genes.There are various treatments for BRONJ, including general use of antibiotics, local wash, mouthwash, operation treatment, hyperbaric oxygen chamber treatment, laser, and autologus bone marrow stem cell transplantation, but no one has satisfied therapeutic efficacy.This paper reviews the research progress of the pathogenesis and treatment of BRONJ. |