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| VDR基因SNPs多态性与新疆维、汉民族育龄女性腰 椎峰值骨密度的关系 |
| Relationship between SNPs polymorphism of vitamin D receptor gene and peak bone mass of the lumbar vertebrae in Uygur and Han women in Xinjiang |
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| DOI： |
| 中文关键词: 骨密度 维生素D受体 基因多态性 育龄女性 |
| 英文关键词:Bone mineral density Vitamin D receptor Gene polymorphism Fertile women |
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| 中文摘要: |
| 目的探讨新疆地区维吾尔族、汉族两民族育龄女性维生素D受体（VDR)基因多态性与腰椎峰值骨密度的关系。方 法分别对新疆地区无亲缘关系、年龄20 -40岁的305例汉族健康妇女和216例维吾尔族健康妇女进行CDX2 (rs11568820) ,TaqI( rs731236) ,Tru9 I( rs757343)位点多态性检测，用定量CT ( QCT)骨密度仪测定腰椎骨密度（BMD)。结果 维、汉族育龄女性腰椎骨峰值出现的年龄段略有不同，但都在35岁达到。两民族女性CDX2(rs11568820)，TaqI(rs731236)， Tru9 I(rs757343)位点基因型及等位基因频率分布均符合Hardy-Weinberg平衡定律;CDX2(rs11568820)基因型频率在维、汉两 民族妇女中比较，差异有显著性(P <0. 05)。TaqI位点T和t等位基因分布频率在维族和汉族育龄女性中差异有有统计学意 义（P <0. 05)。各基因型与BMD的关系显示:CDX2( rs11568820)，TaqI(rs731236)，Tru9 I( rs757343)位点多态性与维族、汉族 腰椎峰值骨密度均无明显相关(P >0. 05)。但VDR基因TaqI携带Tt基因型的骨密度值在汉族与维族妇女比较时存在显著 性差异，同样携带Tt基因型的维族女性骨密度比汉族女性高。Tru9I在汉族女性组中携带Tt基因型，其骨密度比携带tt型和 TT型高，结论 VDR SNPs的基因型与腰椎峰值骨密度具有种族差异性，CDX2( rs11568820)，TaqI ( rs731236)，Tru9 I (rs757343)位点多态性对新疆地区维、汉族育龄女性腰椎峰值骨量无明显影响。 |
| 英文摘要: |
| Objective To investigate the relationship between SNPs polymorphism of vitamin D receptor (VDR) gene and peak bone mass of the lumbar vertebrae in Uygur and Han women in Xinjiang. Methods A total of 305 Han and 216 Uygur healthy women，aging from 20 - 40 years old and no genetic relationship，were selected. The genotypes of CDX2 (rs11568820)，TaqI (rs731236)，and Tru9 I (rs757343) in all the subjects were detected using SNaPshot. The bone mineral density (BMD) of the lumbar vertebrae was detected using quantitative CT (QCT) bone densitometry. Results Although the time of peak BMD of the lumbar vertebrae appeared differently between Han and Uygur women，they all had peak BMD on 35 years old. Hardy4Veinberg Equilibrium was evident for VDR gene polymorphism in Han and Uygur women. There was significant difference of the genotype distribution of CDX2 (rs11568820) between Han and Uyghur women (P < 0. 05). The difference of the frequency distribution of T and t allele gene at TaqI site between Han and Uyghur fertile women was significant (P <0.05). No significant correlation between peak BMD and SNPs polymorphism of VDR gene was found in Uygur and Han women. But BMD of Uygur women with Tt genotype at TaqI site was higher than that of Han women. In Han women，BMD of people with Tt genotype at Tru9I site was higher than that of people with TT and tt genotype. Conclusion The difference of SNPs polymorphism of VDR and peak BMD of the lumbar vertebrae exists between Uygurs and Hans. But the polymorphisms of CDX2 (rs11568820)，TaqI (rs731236)，and Tru9 I (rs757343) of VDR gene have no obvious effect on the peak bone mass in Uygur and Han fertile women. |
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