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| 老年男性骨质疏松合并2型糖尿病患者血清25羟维 生素D水平研究 |
| Study of serum 25-OH vitamin D level in senile male patients with osteoporosis and type 2 diabetes |
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| DOI： |
| 中文关键词: 老年男性 骨质疏松 2型糖尿病 骨密度 维生素D |
| 英文关键词: |
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| 中文摘要: |
| 目的探讨老年男性骨质疏松合并2型糖尿病患者血清25羟维生素D的水平。方法选择2011年3月至2014年5 月我科住院的54例患者，包括老年男性骨质疏松合并2型糖尿病患者27例，年龄70. 78 ±7. 30岁，非糖尿病老年男性骨质疏 松患者27例，年龄71. 44 ±6. 38岁。采用美国Norland双光能X线骨密度检测仪对所有患者进行腰椎L2-L4和左侧股骨近端 (包括Neck、Troch、Ward三角区）骨密度测量，并测定身高、体重、空腹血糖(FBG)、血谷丙转氨酶（ALT)、谷草转氨酶（AST)、 肌酐(CRE)、尿素氮（BUN)。采用酶联免疫吸附法测定两组患者血清25羟维生素D，比较两组25羟维生素D水平。结果 老年男性骨质疏松合并2型糖尿病患者血清25羟维生素D14 38 ±3. 00ng/ml，较非糖尿病老年男性骨质疏松患者25羟维生 素D19. 53 ±8. 96ng/ml低，差异具有统计学意义（P <0. 05);老年男性骨质疏松合并2型糖尿病患者ALT22. 76 ± 11. 73 IU/L、 AST 20. 16 ±7. 65IU/L、CRE 77. 48 ± 20. 29 umol/L、BUN 6. 38 ± 1. 84 mmol/L 与非糖尿病骨质疏松患者 ALT 18. 26 ± 7. 53 IU/ L、AST 19. 33 ±5. 83 IU/L、CRE 77. 11 ± 15. 16 umol/L、BUN 6. 32 ±2. 19 mmol/L 相比，差异无统计学意义（P >0. 05);老年骨质 疏松合并 2 型糖尿病患者 L24、L2、L3、L4、Neck、Troch、ward’ s 三角区的骨密度分别为 1. 01 ±0. 20 g/cm2、0. 98 ±0. 20 g/cm2、 1. 01 ± 0. 21 g/cm2、1. 02 ± 0. 21 g/cm2、0. 82 ± 0. 25 g/cm2、0. 77 ± 0. 20 g/cm2、0. 65 ±0.281 g/cm2 与对照组 0. 96 ± 0. 19 g/cm2、 0. 92 ±0.19 g/cm2、0. 95 ±0. 19 g/cm2、1. 00 ± 0. 22 g/cm2、0. 75 ±0. 18 g/cm2、0.64 ± 0. 13 g/cm2、0. 58 ±0.19 g/cm2 相比较，差 异没有统计学意义(P >0.05)。结论老年男性骨质疏松合并2型糖尿病患者较非糖尿病骨质疏松患者维生素D缺乏更严 重。 |
| 英文摘要: |
| Objective To investigate the serum level of 25 -OH vitamin D in senile male patients with osteoporosis and type 2 diabetes. Methods Fifty^our senile male patients，who were hospitalized in our department from March 2011 to May 2014，were selected. Among all these patients，27 senile osteoporosis patients with type 2 diabetes were included，with an average age of 70. 78 ±7. 30 years old. The other 27 senile osteoporosis patients without type 2 diabetes were also included，with an average of 71. 44 士 6. 38 years old. The bone mineral density (BMD) of L2-L4 and the left proximal femur，including the Neck，the Troch，and the Ward’s triangle，was detected using dual energy X-ay absorptiometry (DEXA，Norland Co.，USA). The height，weight，FBG， ALT，AST，CRE，and BUN in the 2 groups were also detected. The serum 25-OH vitamin D was detected using enzyme linked immunosorbent assay，and the levels of 25 -OH vitamin D between the 2 groups were compared. Results The serum level of 25- OH vitamin D in senile male patients with osteoporosis and type 2 diabetes was 14. 38 士 3. 00ng/ml，which was significantly lower than that in senile male osteoporosis patients without type 2 diabetes (19. 53 士 8. 96ng/ml; P < 0. 05). The serum levels of ALT， AST，CRE，and BUN in senile male osteoporosis patients with type 2 diabetes were 22. 76 士 11. 73 IU/L，20. 16 士 7. 65 IU/L， |
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