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| 骨转换标志物监测双膦酸盐治疗反应 |
| Bone turnover markers in monitoring the early response to bisphosphonates treatment |
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| DOI：10.3969/j.issn.1006-7108.2014.10.007 |
| 中文关键词: 骨转换标志物 双膦酸盐 监测 |
| 英文关键词:Bone turnover marker Bisphosphonates Monitoring |
| 基金项目: |
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| 中文摘要: |
| 目的 利用骨转换标志物监测双膦酸盐治疗的早期反应。方法 对60例新接受双膦酸盐治疗的绝经后骨质疏松症患者，在治疗前和16周时监测血清β-CTX和P1NP，判断治疗有效性 。结果 治疗前β-CTX：0.390±0.230 ng/ml，P1NP：51.445±25.955 ng/ml；24例存在骨转换标志物升高，36例骨转换标志物正常；治疗后血清β-CTX：0.133±0.120 ng/ml，P1NP：18.853±10.225 ng/ml，均非常显著降低，治疗有效率达95%。结论 β-CTX和P1NP是监测双膦酸盐早期治疗反应的有效方法。 |
| 英文摘要: |
| Objective To monitor the early response to bisphosphonates treatment with bone turnover markers. Methods Serum β-CTX和P1NP were monitored for 60 postmenopausal women before and 16 weeks after the bisphosphonates treatment, in order to evaluate the efficacy of the treatment. Results β-CTX was 0.390±0.230 ng/ml and P1NP was 51.445±25.955 ng/ml before the bisphosphonates treatment. Bone turnover was high in 24 patients and normal in 36 before the treatment. β-CTX was 0.133±0.120 ng/ml and P1NP was 18.853±10.225 ng/ml after the bisphosphonates treatment. The significant reduction in β-CTX和P1NP was present. The efficacy of the treatment was 95%. Conclusion The measurement of β-CTX and P1NP are effective method for monitoring the bisphosphonates treatment. |
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