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| 鲑鱼降钙素影响骨质疏松患者血清胰岛素样生长因子、白介素6和肿瘤坏死因子α的临床观察 |
| Clinical observation of the effect of miacalcic on the serum IGF-1, IL-6 and TNF-α in patients with osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2014.10.020 |
| 中文关键词: 骨质疏松 IGF-1 IL-6 TNF-α 鲑鱼降钙素 |
| 英文关键词:Osteoporosis IGF-1 IL-6 TNF-α, Miacalcic |
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| 中文摘要: |
| 目的 研究鲑鱼降钙素对骨质疏松患者骨密度和体内细胞因子的影响。方法 将本院60例骨质疏松患者随机分成两组，对照组30例口服钙尔奇D 1片/天，观察组30例在对照组治疗方案基础上加用鲑鱼降钙素。治疗前后检测两组患者第2-4腰椎和股骨颈骨密度（Bone Mineral Density，BMD）、胰岛素样生长因子-1（Insulin-Like Growth Factor-1,IGF-1）、血清白细胞介素6（Interleukin-6，IL-6）、肿瘤坏死因子α（Tumor Necrosis Factor-α，TNF-α）的变化，观察患者临床症状的改善。结果 （1）观察组第2-4腰椎和股骨颈BMD升高较对照组明显（P<0.05）；（2）观察组患者IGF-1、IL-6以及TNF-α水平明显低于对照组（P<0.01）；（3）观察组患者骨痛改善率高于对照组（P<0.05）。（4）无论治疗组还是对照组的BMD均与IGF-1呈正相关，与IL-6和TNF-α呈负相关。结论 鲑鱼降钙素可有效提升骨质疏松患者腰椎和股骨颈BMD，并能够改善IGF-1、IL-6以及TNF-α水平，有效缓解疼痛。 |
| 英文摘要: |
| Objective To evaluate the effect of miacalcic on bone mineral density (BMD) and cytokines in the osteoporotic patients. Methods Sixty patients with osteoporosis were equally randomly assigned into 2 groups. Patients in control group (30 cases) received 600mg Caltrate per day. Patients in observation group (30 cases) received miacalcic besides Caltrate. The BMD of L2-4 lumbar spine and the femoral neck, insulin-like growth factor-1 (IGF-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were determined before and after the treatment. Clinical symptoms were observed. Results BMD of the L2-4 lumbar spine and the femoral neck were higher in observation group than in control group (P<0.05). The serum levels of IGF-1, IL-6, and TNF-α were lower in observation group than in control group (P<0.01). Pain was significantly relieved in the treatment group compared to control group (P<0.05). BMD change was positively correlated to IGF-1 but negatively correlated to IL-6 and TNF-α in both groups. Conclusion Miacalcic is effective to improve BMD and to relieve pain in patients with osteoporosis. It can improve the levels of IGF-1, IL-6, and TNF-α. It can effectively relieve pain. |
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