Objective To evaluated the effect of simvastatin on bone mineral density (BMD) of the calcaneus in postmenopausal women with hyperlipidemia. Methods BMD of the calcaneus of 885 postmenopausal women with hyperlipidemia (TC>5.18mmol/L or LDL-C>3.37mmol/L) were studied. Simvastatin was used in these women. According to the T-score, normal bone mass, osteopenia, and osteoporosis were diagnosed. Results BMD of the calcaneus was 305.3± 59.2 mg/cm2 before the treatment. The number of people with normal bone mass, osteopenia, and osteoporosis were 115, 446, and 324, respectively. After simvastatin administration (20 mg/d) for 3 months, the BMD was 309.7±56.3mg/cm2. The number of people with normal bone mass, osteopenia, and osteoporosis were 117, 459, and 319, respectively. After a 12-month treatment, BMD of the calcaneus was 312.5±60.9 mg/cm2. The number of people with normal bone mass, osteopenia, and osteoporosis were 122, 460, and 303, respectively. Conclusion After a 12-month simvastatin (20mg/kg/d) administration, BMD of the calcaneus increases in postmenopausal women with hyperlipidemia. It can not affect the risk of osteoporosis for these women. |