| Bone diseases are one kind of the motor system diseases involving of bone, joint, tendons and fascia. They include osteoporosis, rickets, osteosclerosis, femoral head necrosis, fractures, etc. Several factors affect the development of the diseases, such as genetic, environmental, endocrinal and nutritional factors. In addition to calcium, phosphorus and vitamins which are associated with bone diseases, a number of trace elements are also involved in the growth, development and metabolism of the bone. Furthermore, various trace elements play the different roles in bone metabolism and diseases. Therefore, deficiency of trace elements, which participate in bone metabolism and regeneration, may cause the disorder of bone growth, resorption, and mineral deposition, leading to different types of bone diseases. This paper reviews the distribution of trace elements in the bone, the regulation of bone metabolism, bone diseases due to the deficiency of trace elements, and supplementation of trace elements for prevention and treatment of bone diseases, thus providing theoretical basis for clinical diagnosis and therapy of bone diseases for trace element deficiency. |