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| 绝经后骨松患者替勃龙治疗半年骨代谢指标的变化 |
| Changes of bone metabolic markers in patients with postmenopausal osteoporosis before and after six-nonth tibolone treatment |
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| DOI：10.3969/j.issn.1006.7108.2014.11.009 |
| 中文关键词: 骨质疏松症 绝经后 骨密度 骨代谢指标 替勃龙 |
| 英文关键词:Osteoporosis Postmenopause Bone mineral density Bone metabolic markers Tibolone |
| 基金项目:安徽省临床医学技术应用项目（2008A029) |
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| 中文摘要: |
| 目的 观察绝经后骨质疏松（PMOP)患者替勃龙治疗半年骨特异性碱性磷酸酶（BALP)和抗酒石酸酸性磷酸酶(TRAP)的变化。方法 绝经后女性按双能X线骨密度检查结果分为PMOP组（骨松组，N = 30例）及非骨松组（N =30 例），30例育龄期骨密度正常女性为对照组，测定其血清BALP、TRAP水平。骨松组服用替勃龙（2. 5 mg/d)6个月，测定治疗前及治疗后3、6月骨密度(BMD)，治疗前及治疗后1、3、6月血清TRAP、BALP水平变化。结果 与对照组比较，绝经后骨松组及非骨松组的血清TRAP、BALP水平均明显升高，差异有显著性（P <0.01)；骨松组血清TRAP、BALP水平较非骨松组进一步升高，差异有显著性（P <0. 01)。骨松组应用替勃龙治疗3月后BMD较治疗前增加，但差异无显著性（P > 0.05)，治疗6月后BMD与治疗前相比显著增加（P < 0. 05);其血清TRAP、BALP水平在治疗1月后，与治疗前相比较均开始降低，差异有显著性（P < 0. 05)，治疗3月后，骨代谢指标均下降，差异有显著性（P < 0. 01)，治疗6月后，其水平进一步 下降(P <0.01)。结论 骨代谢生化指标TRAP和BALP的检测，可以早期评价骨转换情况，联合BMD测定可以及时监测替勃龙的药物疗效。 |
| 英文摘要: |
| Objective To observe the changes of bone specific alkaline phosphatase ( BALP) and tartrate-resistant acid phosphatase (TRAP) in patients with postmenopausal osteoporosis (PMOP) after 6-month tibolone treatment. Methods All of 60 postmenopausal women were divided to osteoporosis group (n = 30) and non-osteoporosis group (n =30)，according to dual?energy X-ray absorptiometry measurement results. Control group contained 30 childbearing-age women with normal bone mineral density (BMD). Serum BALP and TRAP were detected. Women in PMOP group received tibolone (2. 5 mg/d) treatment for 6 months. BMD were measured at 0，3，and 6 months，and BALP and TRAP were detected at 0，1，3，and 6 months. Results Serum BALP and TRAP in PMOP group and non-PMOP group had significantly higher levels compared to those in control group (P<0.01). BALP and TRAP in PMOP group increased further more than those in non-PMOP group (P <0. 01). BMD in PMOP group increased after 3-month tibolone treatment but without significant difference (P >0.05). Significant improvement was observed at 6 month (P < 0. 05). BALP and TRAP in PMOP group significantly decreased at 1 month compared to baseline (P < 0.05)，and further decline appeared at 3 and 6 months (P < 0. 01). Conclusion Bone metabolic biochemical markers，such as BALP and TRAP,,can provide an early evaluation of bone turnover. It can timely monitor the drug efficacy of tibolone when combines with BMD measurement. |
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