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| 绝经后骨质疏松症经脉冲电磁场治疗前后甲状旁腺激素、25OHD2和25OHD3的对比性研究 |
| Comparison study of parathyroid hormone，25OHD2，and 25 OHD3 before and after the treatment of electromagnetic field pulse in postmenopausal osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2014.11.016 |
| 中文关键词: 绝经后骨质疏松症 脉冲电磁场 甲状旁腺激素 25羟基维生素D2 25羟基维生素D3 |
| 英文关键词:Postmenopausal osteoporosis Pulsed electromagnetic fields Parathyroid hormone 25 hydroxy vitamin D2 25 hydroxy Vitamin D3 |
| 基金项目:贵州省科技厅联合基金项目(黔科合LS字[2012] 046号) |
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| 中文摘要: |
| 目的 对比性分析绝经后骨质疏松症(POP)经脉冲电磁场治疗前后PTH、25OHD2、25OHD3指标值的变化情况，探讨脉冲电磁场治疗POP的临床价值。方法 以我院收治的100例绝经后患骨质疏松症患者为观察组，另选择同期体检的80例健康者为对照组。分别对2组对象的血清PTH、25OHD2、25OHD3指标及骨密度（BMD)进行检测，对比分析治疗前2组对象的各指标值，分析PTH、25OHD2+25OHD3与BMD的相关性。同时，对比分析观察组患者治疗前后各指标值的变化情况。结果 观察组患者治疗前，其血清PTH指标平均值高于对照组(P <0.05)；血清25OHD2、25OHD3指标平均值均低于对照组（P < 0.05)。观察组患者血清PTH与BMD呈负相关（r = -0.57，P < 0. 05);25OHD2 +25OHD3与BMD呈正相关（r =0.68，P< 0.05)。治疗后较治疗前，观察组患者的血清PTH水平降低（P <0.05);血清25OHD2、25OHD3水平及BMD升高（P <0.05)。 结论 脉冲电磁场通过对POP患者血生化及骨代谢的调节，能够有效提高骨密度，起到治疗POP的临床效果。 |
| 英文摘要: |
| Objective To analysis comparatively the changes of PTH，25OHD2，and 25OHD3 before and after electromagnetic pulse treatment in postmenopausal osteoporosis ( POP) ,and to evaluate the clinical value of pulsed electromagnetic field therapy. Methods One hundred postmenopausal osteoporotic patients in our hospital were selected as observation group，and 80 healthy people coming for physical examination at the same period were selected as control group. Serum PTH，25OHD2，25OHD3，and bone mineral density (BMD) of people in 2 groups were detected. Each index in 2 groups before the treatment was analyzed. The correlation between PTH，25OHD2 +25OHD3，and BMD was analyzed. At the same time，the changes of each index before and after the treatment in patients were observed. Results The serum PTH in patients of observation group before treatment was higher than that of control group (P < 0. 05)，but the average serum levels of 25OHD2 and 25 OHD3 were lower than those in the control group (P < 0. 05). PTH in the observation group was negatively correlated with BMD ( r = -0.57，P <0. 05)，but 25OHD2+ 25OHD3 was positively correlated with BMD ( r = 0. 68，P < 0. 05). PTH in the observation group decreased after the treatment compared to that before treatment (P < 0. 05)，but the serum 25OHD2，25OHD3，and BMD increased (P < 0. 05). Conclusion Pulsed electromagnetic field therapy can effectively improve bone density of patients with POP through the regulation of bone metabolism and biochemical markers，resulting in the clinical outcome of POP treatment. |
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