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| 骨质疏松症患者血清25-羟维生素D水平的研究 |
| The study of serum 25-hydroxyvitamin D status of patients with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2014.11.017 |
| 中文关键词: 骨质疏松症 25 4羟维生素D 维生素D缺乏 |
| 英文关键词:Osteoporosis Serum 25-hydroxyvitamin D Vitamin D deficiency |
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| 中文摘要: |
| 目的 调查了解西安地区骨质疏松症患者体内维生素D水平的状况。方法 随机选取2012年12月-2013年11月我科440例骨质疏松症患者，采集其清晨空腹静脉血，用Cobase 6000型电化学发光仪(瑞士罗氏诊断)检测血中25( OH) D的水平，按照2012年12月-2013年5月为冬春季和2013年6月-2013年11月为夏秋季进行分组，用SPSS13. 0软件进行数据分析。结果 共调查了440例骨质疏松症患者，其中女性患者数量远大于男性患者，这些患者普遍存在着维生素D水平不足现象，其中维生素D严重缺乏和缺乏所占比例较大，男女两组在年龄和血清25(OH)D水平上均无统计学差异，而且冬春季患者体内维生素D的水平要低于夏秋季的患者。结论 本研究显示西安地区骨质疏松症患者维生素D不足现象比较普遍，男性女性之间无明显差别，而且体内维生素D水平与季节的变化有关，为骨质疏松症的防治提供一定的数据参考。 |
| 英文摘要: |
| Objective To investigate the serum 25-hydroxyvitamin D status of patients with osteoporosis in Xi'an. Methods Four hundred and forty osteoporotic patients were randomly selected from December in 2012 to November in 2013 in Xian. Fasting blood samples were collected. Serum 25 -hydroxyvitamin D was determined using electrochemiluminescence (Rocher,Swiss). These patients were divided in the winter-spring group (from December 2012 to May 2013) and summer-autumn group (from June 2013 to November 2013). The data were analyzed using a SPSS13. 0 software. Results Four hundred and forty osteoporotic patients were investigated，in which female patients were much more than male ones. Vitamin D inadequacy existed generally in osteoporotic patients. Among them， vitamin D deficiency and critical deficiency were in a greater ratio. There was no statistic difference in the level of vitamin D between the male and the female. Vitamin D level in osteoporotic patients in winter-spring group was lower than that in patients，in summer-autumn group. Conclusion The study shows that the prevalence of vitamin D deficiency in osteoporotic patients in Xi'an was common. No difference exists between males and females. The vitamin D level is associated with the change of the season. This study provides certain reference for the prevention and treatment of osteoporosis. |
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