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| 抗CCP抗体在类风湿性关节炎诊断中的应用进展 |
| Progress of anti-CCP antibody in the application of diagnosis of rheumatoid arthritis |
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| DOI：10.3969/j.issn.1006.7108.2014.11.025 |
| 中文关键词: 抗CCP抗体 类风湿性关节炎 类风湿因子 |
| 英文关键词:Anti-CCP Rheumatoid arthritis Rheumatoid factors |
| 基金项目:国家自然科学基金面上项目赞助课题(81072546) |
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| 中文摘要: |
| 目前类风湿关节炎的诊断检查有炎性标志物(包括血沉和C反应蛋白)检测，免疫复合物和补体检测，关节滑液检测以及自身抗体检测。这些指标经常伴随类风湿关节炎的活动而改变，早期诊断主要依靠的是自身抗体检测。抗环瓜氨酸肽 (cyclic citrullinated peptide，CCP)抗体是一种抗角蛋白抗体，在类风湿性关节炎的敏感度和特异度较类风湿因子高。发病一年内，类风湿性关节炎患者大部分血清中可检测到抗CCP抗体的存在，同时抗CCP抗体阳性也可以用来预测严重破坏的类风湿性关节炎。因此，抗CCP抗体对于类风湿性关节炎的早期诊断及预后评估是极有帮助的。本文综述了近年来抗CCP抗体对于诊断类风湿关节炎的应用进展。 |
| 英文摘要: |
| Currently the markers for the diagnosis of rheumatoid arthritis include inflammatory makers ( including blood sedimentation and C-reactive protein)，immune complexe and complement detection，detection of joint synovial fluid，and detection of autoantibodies. These indicators change with the activity of arthritis. Early diagnosis relies mainly on detection of autoantibodies. Anti-cyclic citrullinated peptide antibody (anti-CCP) is a kind of anti-keratin antibody，having higher sensitivity and specificity than the rheumatoid factor in diagnosis of rheumatoid arthritis. During the first year of rheumatoid arthritis，the existence of anti-CCP can be detected in the serum of most of these people. Positive anti-CCP can also be used to predict serious damage. Therefore，anti-CCP is extremely helpful in early diagnosis and prognosis assessment of rheumatoid arthritis. In this paper，the recent application of anti- CCP in the diagnosis of rheumatoid arthritis is reviewed. |
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