| Objective To study the relationship between osteopontin ( OPN) and bone mineral density ( BMD) and bone turnover markers in postmenopausal women, and to explore the clinical value of OPN in postmenopausal osteoporosis.Methods One hundred and twenty-five postmenopausal women were selected in the study.BMD of the lumbar spine 1-4 and the left femoral neck was measured using dual-energy X-ray absorptiometry.Levels of serum procollagen type I N-terminal propeptide ( PINP ) , β-crosslaps (β-CTX), 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH), OPN, osteocalcin (OC), calcium (Ca), and phosphorus(P) were measured.Results ①Osteopontin level in osteoporosis group was significantly higher than that in osteopenic and normal group (F=0.118, P=0.000).②BMD and Ca were negatively correlated, while age, β-CTX, and OC were positively with OPN ( all P <0.05 ) .③Multiple regression analysis showed that BMD of left femoral neck and Ca were independent predictors of the serum OPN level.Conclusion High level of OPN is associated with low BMD, increased level ofβ-CTX, and the lack of Ca, which enriches the existing clinical evidence and provide a new idea for controlling postmenopausal osteoporosis. |