双能X线骨密度仪精密度和准确度的研究
Study of the precision and accuracy of dual-energy X-ray bone densitometry
投稿时间:2014-08-05  
DOI:
中文关键词:  双能X线吸收法  质量控制  长期精密度  短期精密度  短期准确度
英文关键词:Dual-energy X-ray absorptiometry  Quality control  Long-term precision  Short-term precision  Short-term accuracy
基金项目:
作者单位E-mail
金超岭 中日友好医院核医学科100029 北京  
王猛   
李红磊   
刘鸿娥   
颜珏  yanjue3@163.com 
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中文摘要:
      目的:通过测量长、短期精密度和短期准确度对双能X线吸收法( dual-energy X-ray absorptiometry ,DXA)骨密度仪进行质量控制。方法①长期精密度:对质量保证(Quality Assurance,QA)模块连续1年的测试数据进行统计分析,分别计算其高、中、低骨密度、均值骨密度、骨矿盐含量、投影面积的变异系数( coefficient of variation ,CV);②短期精密度:取连续25天的QA模块测试数据,计算高、中、低骨密度平均值和标准差(standard deviation,SD),制作Shewhart质控图。另外选取30名志愿者,分别测量L1-4椎体,双侧股骨颈、大粗隆、Ward's三角、全髋关节的骨密度(bone mineral density,BMD)值,计算均方根变异系数( root mean square of the CV ,RMS-CV);③短期准确度:取连续25天的QA模块测试数据,计算高、中、低骨密度的准确度。结果①长期精密度:QA模块测量高、中、低骨密度、均值骨密度、骨矿盐含量、投影面积的CV分别为0.37%、0.37%、0.41%、0.43%、0.47%、0.12%;②短期精密度:连续25天QA模块测试数据均符合Shewhart 法则;30例受试者L1-4椎体,双侧股骨颈、大粗隆、Ward's 三角、全髋关节各测量部位的RMS-CV 分别为1.3%、0.8%、0.9%、1.2%、1.3%、1.5%、1.6%、0.6%、0.6%;③短期准确度:连续25天QA模块测试数据的高、中、低骨密度的准确度分别为-0.07%、0.10%、0.60%。结论进行长、短期精密度和准确度测试能反映双能X线吸收骨密度仪的一致性和可靠性,可有效提高骨质疏松的流行病学研究、诊断、治疗、药物试验研究的可信度。
英文摘要:
      Objective To study the long-term and short-term precision and short-term accuracy of quality assurance ( QA) in using dual-energy X-ray absorptiometry ( DXA ) .Methods 1 ) Long-term precision: the consecutive 1-year data from QA phantom were statistical analyzed, and the high-, middle-, and low-bone mineral density ( BMD ) , mean BMD, bone mineral content, and projected area of coefficient of variation (CV) were calculated.2)Short-term precision:the data of QA phantom of 25 consecutive days were collected.The mean and standard deviation ( SD) of the high-, middle-, and low-BMD were calculated. The Shewhart chart was created.BMD of the L1-4 vertebral body, bilateral femoral neck, the greater trochanter, ward triangle, and the total hip joint of 30 volunteers was measured.The root mean square of the CV (RMS-CV) was calculated.3) Short-term accuracy:the data of QA phantom of 25 consecutive days were collected.The accuracy of the high-, middle-, and low-BMD were calculated.Results 1) Long-term precision:the CV of high-, middle-, low-BMD, mean BMD, bone mineral content, and projected area was 0.37%, 0.37%, 0.41%, 0.43%, 0.47%, and 0.12%, respectively.2) Short-term precision:the data of QA phantom for 25 consecutive days met the Shewhart rule.The RMS-CV value of L1-4 vertebral body, the bilateral femoral neck, the the bilateral greater trochanter, the the bilateral Ward triangle, and the total hip joint of 30 volunteers was 1.3%, 0.8%, 0.9%, 1.2%, 1.3%, 1.5%, 1.6%, 0.6%, and 0.6%, respectively.3) Short-term accuracy:the accuracy of the data of high-, middle -, low-BMD yielded by scanning QA phantom for 25 consecutive days was -0.07%, 0.10%, and 0.60%, respectively.Conclusion The consistency and reliability of DXA can be reflected by the long-term and short-term precision and accuracy trail.It can effectively raise the credibility of the epidemiological investigation, diagnosis, treatment, and drug testing of osteoporosis.
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