| Objective To observe the efficacy of zoledronic acid in the treatment of osteoporotic vertebral compression fracture ( OVCF) after percutaneous vertebroplasty ( PVP) .Methods Two hundred and forty OVCF patients treated with PVP from July 2010 to Feberary 2013 were randomly divided into 2 groups.The patients in the treatment group received intravenous 5 mg zoledronic acid once a year after 3 days of the operation.The patients in the control group received PVP only.The patients in both groups received oral vitamin D3 and caltrate daily.The VAS scores, BMD of the lumbar spine, PINP, and β-CTX were tested before and 1-, 3-, 6-, 9-, and 12-month after the operation.All the results were analyzed statistically.Results All the 240 patients in both groups were followed up for 1 year.Compared to those in the control group, the VAS scores, BMD of lumbar spine, PINP, andβ-CTX were significantly different to those in the control group.The patients in the treatment group had a better compliance and lower rate of new fractures of the vertebral body.Conclusion Zoledronic acid administration once a year can increase BMD, ruduce the pain and fracture risk, and improve the quality of life in OVCF patients.Zoledronic acid treatment should be used for OVCF patients after PVP operation. |