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| 血清25-羟维生素D浓度检测对膝骨关节炎临床诊疗意义 |
| The clinical significance of the detection of serum 25-hydroxyvitamin D in the diagnosis and treatment of knee osteoarthritis |
| 投稿时间：2013-10-23 |
| DOI： |
| 中文关键词: 骨关节炎 维生素D 25-羟维生素D 罗氏诊断 |
| 英文关键词:Osteoarthritis Vitamin D 25-hydroxyvitamin D Roche Diagnostics |
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| 中文摘要: |
| 目的：研究与探讨血清25－羟基维生素D浓度检测对膝骨关节炎临床诊疗的指导意义。方法随机抽取2011年6月至2011年10月以及2012年6月至2012年10月期间骨科门诊主诉有膝关节疼痛患者1174名，采用罗氏诊断试剂盒检测患者血清中的25－羟基维生素D浓度。结果1174例患者平均年龄（53．61±15．10）岁，血清25－羟维生素D浓度平均值为15．55 ng／ml，维生素D缺乏者（＜20 ng／ml）占48．12％（524例），其中严重缺乏者（＜10 ng／ml）占26．35％（287例）。2011年测得血清25－羟基维生素D浓度平均值为13．27 ng／ml（参考值为11．10～42．90 ng／ml）；2012年测得血清25－羟基维生素D浓度平均值为22．53 ng／ml（参考值为20～32 ng／ml）。结论血清25－羟基维生素D浓度检测在膝骨关节炎诊疗中具有重要指导意义。本次研究中应用的罗氏诊断血清25－羟维生素D3检测试剂参考值有波动，直接导致2011年度与2012年度同期所检测出的患者血清25－羟基维生素D浓度存在一定的偏差。 |
| 英文摘要: |
| Objective To assess the guiding significance of the detection of serum 25-hydroxyvitamin D in the diagnosis and treatment of knee osteoarthritis.Methods A total of 1174 subjects with the main complain of osteoarthritis pain in the out-door department of orthopedics from June 2011 to October 2011 and from June 2012 to October 2012 were randomly recruited.Serum 25-hydroxyvitamin D of the patients was examined using Roche Diagnostics kit.Results The mean age of 1174 patients was 53.61 ± 15.10 years.The mean 25-hydroxyvitamin D concentration was 15.55 ng/ml.The patients with vitamin D deficiency ( <20 ng/ml) accounted for 48.12%(524 cases); including 26.35% (287 cases) with severe deficiency ( <10 ng/ml).The mean 25-hydroxyvitamin D concentration tested in 2011 was 13.27 ng/ml ( reference value 11.10-42.90 ng/ml ) . The mean 25-hydroxyvitamin D concentration tested in 2012 was 22.53 ng/ml ( reference value 20-32 ng/ml) .Conlusion Detection of serum vitamin D is of importance in the diagnosis and treatment of knee osteoarthritis.The reference of Roche Diagnostics kit of 25-dihydroxyvitamin D3 used in this study is fluctuated, directly leading to the patient bias of serum 25-hydroxyvitamin D concentration in 2011 and 2012. |
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