| Osteoporosis is a kind of metabolic disease characterized by bone mass loss and bone microstructure destruction, leading to fragility of the bone and increase of bone fracture risk.The disease has become one of the popular diseases that affect people’ s quality of life.Its etiology is various and molecular mechanism is complex.Continuous formation of ROS is an inescapable consequence of the human metabolism in an oxygen-rich environment.Oxidative stress occurs in the condition that the ROS balance between generation and elimination is broken because of aging, disease and so on in the human body.More and more studies have found that oxidative stress induced by excessive ROS plays an important role in osteoporosis.Excessive ROS regulates multiple signaling pathways via a variety of cytokines, the activation or inhibition of enzyme activity, and up-regulation or down-regulation of the expression of receptor ligand.Ultimately it affects the gene expression within the nucleus, promotes apoptosis of bone formation related cells such as bone marrow mesenchymal stem cells ( BMSCs) , osteoblasts, and osteocytes, promotes proliferation and differentation of osteoclasts, and results in the lag of bone formation behind bone resorption.As a result, the dynamic balance between osteoclastic bone resorption and osteoblastic bone formation is broken, leading to osteoporosis.This article reviewes the effect of oxidative stress induced by ROS on bone formation related cells, osteoclasts, and bone matrix, and provides a basis for the further research of osteoporosis. |