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| 唑来膦酸对骨质疏松骨含量的影响 |
| Effect of zoledronic acid on bone mass in osteoporotic patients |
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| DOI： |
| 中文关键词: 密固达 骨密度 骨量 钙剂 活性维生素D 骨质疏松骨折 |
| 英文关键词:Aclasta Bone mineral density Bone mass Calcium Activated vitamin D Osteoporotic fracture |
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| 中文摘要: |
| 目的探讨双膦酸盐对骨质疏松骨量的影响。方法选绝经后骨质疏松症患者59例，随机分为治疗组和对照组，其中 治疗组(30例），一次性静脉滴注唑来膦酸注射液5 mg，后次日始日一次静点0. 9%生理盐水100 ml +葡萄糖酸钙10 ml(1g)3 ~5天，同时碳酸钙600 mg/d，活性维生素D3 400IU/d 口服;对照组(29例），给予同剂量的碳酸钙及活性维生素D3 口服，6个 月后复査评价疗效。结果患者临床疗效比较，治疗后患者BMD值有不同程度增髙，其中骨含量一项升髙明显，疼痛感明显 下降，与治疗前比较，差异有统计学意义(P <0.05)，随访期间无一例骨质疏松性骨折发生。结论双膦膦酸联合钙剂治疗绝 经后骨质疏松，能显著改善患者的疼痛症状，有效的改善及维持BMD水平，增加骨量降低了骨质疏松骨折的发生率。是治疗 绝经后骨质疏松症的安全有效方法。 |
| 英文摘要: |
| Objective To explore the influence of bisphosphonates in bone mass in osteoporosis. Methods Fifty-nine patients with postmenopausal osteoporosis were selected and were randomly divided into treatment group (n =30) and control group (n = 29). In treatment group，patients received intravenous 5mg zoledronic acid (Aclasta) injection once，and continued with 0.9% normal saline 100ml and calcium gluconate 10 ml (1g) once a day for 3 -5 days. They also took calcium carbonate 600mg/d and active vitamin D3 400 iu/d. In control group，patients were given oral calcium 600 mg/d and active vitamin D3 400 iu/d. The efficacy was evaluated after 6 months. Results After the treatment，BMD of patients increased in varying degree. Bone mineral content was elevated significantly. The pain decreased significantly. The difference was statistically significant ( P < 0. 05) compared with that before treatment. No osteoporotic fractures occurred during the follow-up. Conclusion Bisphosphonates combining with calcium can significantly relieve the pain symptom， improve and maintain the BMD level， increase bone mass and reduce the incidence of osteoporotic fractures in the treatment of postmenopausal osteoporosis. It is a safe and effective method for treatment of postmenopausal osteoporosis. |
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