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| miRNA在干细胞成骨分化中的调控作用 |
| Regulatory role of miRNA in osteogenic differentiation of stem cells |
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| DOI： |
| 中文关键词: miRNA 干细胞 成骨分化 信号通路 转录因子 |
| 英文关键词:miRNA Stem cells Osteogenic differentiation Signal pathway Transcription factor |
| 基金项目: |
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| 中文摘要: |
| MkroRNA(miRNA)即微小RNA，是广泛存在于真核生物中的一类非蛋白基因表达调控因子;干细胞的成骨分化是一系 列基因程序表达、精确调控的结果;而近年来研究证明，干细胞的成骨分化受到miRNA的严格调控，干细胞成骨分化的主要信 号通路及相关转录因子均受到miRNA的调控。本文就miRNA对BMPs/TGFp、Wnt/p - catenin等干细胞成骨分化的主要信号 通路的调控作用及机制、miRNA对Runx2、Osterix等成骨分化的特征性下游转录因子的调控机制作一综述。目前如何可控制 地使干细胞定向成骨分化是组织工程医学的热点，而研究miRNA在成骨分化过程中的调控作用将为这一问题提供新的解决 思路和策略。 |
| 英文摘要: |
| miRNA is a non-protein regulation factor of gene expression and widely exists in eukaryotic organisms. The osteogenic differentiation of stem cells is the result of a series of gene expression program and precise regulation. Recent studies have shown that osteogenic differentiation of stem cells is strictly regulated by miRNA，and the main signaling pathways and transcription factors are regulated by the miRNA. This paper reviews the regulation mechanism of miRNA on major signaling pathways such as BMPs/ TGFp and Wnt/(3-catenin， and on the characteristic downstream transcription factors as Runx2 and Osterix. Currently， the regulation and control of osteoblast differentiation by stem cells is the hot issue in engineering medicine. Study the role of miRNA in regulating osteogenic differentiation process provides new ideas and strategies to solve the problem. |
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