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| MicroRNA调控骨髓间充质干细胞成脂分化途径的研 究进展 |
| Research progress of microRNA-mediated adipogenic differentiation pathway of BMSCs |
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| DOI： |
| 中文关键词: mkroRNA ；骨髓间充质干细胞 脂肪细胞 成脂分化 |
| 英文关键词:MicroRNA Bone mesenchymal stem cells Adipocytes Adipogenic differentiation |
| 基金项目: |
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| 摘要点击次数: 1132 |
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| 中文摘要: |
| 骨质疏松症患者骨髓间充质干细胞（BMSCs)成骨分化能力减弱，成脂肪分化能力增强，脂肪组织增多，进而导致骨量 减少，可能是导致骨质疏松的原因之一。mioroRNA是一类起源于内源性转录物的单链非编码RNA，在BMSCs向脂肪细胞分 化及细胞发育成熟的过程中起重要的调控作用。本文通过检索有关BMSCs、mkroRNA、成脂肪细胞分化的相关文献并进行综 述，阐明了 mkroRNA通过调节Wnt、BMP和TGF-P信号通路上因子的表达来决定BMSCs向脂肪细胞分化，再通过调节 PPAR、C/EBP的表达来促使脂肪细胞成熟。因此，深人研究mkroRNA介导的BMSCs成脂肪细胞分化途径，将为我们深人了 解骨质疏松的发病机制具有重要意义。 |
| 英文摘要: |
| In the osteoporotic patients， the ability of osteoblastic differentiation decreases in bone mesenchymal stem cells (BMSCs) but the ability of adipogenic differentiation increases，leading to the bone mass loss. This can be one of the reasons of osteoporosis occurrence. MicroRNA is a class of non-coding small RNA originating from the endogenous transcription factors and plays an important role in the regulation of adipogenetic differentiation of BMSCs and adipocyte maturation. The article reviews the literatures concerning BMSCs，microRNA，and adipogenesis. It is found that microRNA regulates the adipogenic differentiation of BMSCs by controlling the expression of related factors in Wnt，BMP，and TGF-p signal pathways and promotes the maturation of adipocytes by regulating the expression of PPAR and C/EBP. Therefore，it is important to make comprehensive research on the mechanism of microRNA regulation of adipogenesis by BMSCs. |
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