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| 炎症相关骨质疏松症的发病机制 |
| The pathogenesis of inflammation-induced osteoporosis |
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| DOI： |
| 中文关键词: 骨质疏松症 炎症 |
| 英文关键词:Osteoporosis Inflammation |
| 基金项目: |
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| 摘要点击次数: 1097 |
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| 中文摘要: |
| 炎症相关骨质疏松症是指炎症特别是系统性炎症引起的骨量减少、骨质破坏。近期的研究发现多种炎性疾病与骨质疏 松症相关，炎症引起骨质疏松的发病涉及环氧化酶-2(COX-2)、白细胞介素、肿瘤坏死因子a(TNF-alpha)、RANKL/RANK/ OPG系统、C反应蛋白、一氧化氮（nitric oxide)、端粒酶等，发病机制的研究促进了 denosumab等骨质疏松新药的研发。 |
| 英文摘要: |
| Inflammation-induced osteoporosis refers to osteopenia and bone destruction caused by inflammation especially systemic inflammation. Recent research indicates that multiple inflammatory diseases are related to osteoporosis. The pathogenesis of inflammation-induced osteoporosis involves TNF-alpha， interleukins， RANKL \ RANK \ OPG pathway， etc. Research of the pathogenesis helps to develop new anti-osteoporosis drug such as denosumab. |
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