| Objective To observe the clinical efficacy of Jintiange capsule in treatment of primary osteoporosis, and to compare the effect between Jintiange capsule and Caltrate with vitamin D3 tablet. Methods One hundred and sixty patients with primary osteoporosis from the outdoor department of our hospital were diagnosed using dual-energy X-ray absorptiometry. They were divided into the study group (Jintiange group, n=80) and the control group (Caltrate group, n=80) using random number table method. Patients in the study group were treated with Jintiange capsule, and patients in the control group were treated with Caltrate with vitamin D3 tablet. The treatment lasted for 9 months. The symptom score was observed before and 3, 6, and 9 months after the treatment. The bone mineral density (BMD) was observed before and 9 months after the treatment. The data of the symptom score and BMD were evaluated and summarized. The liver function, renal function, and blood calcium were examined before and 3, 6, and 9 months after the treatment. Results All patients were followed up without loss. After the treatment for 3 months, the lumbar and back pain, debilitation, and gait difficulty in both groups were all different comparing to those before the treatment (P<0.01). The difference between the groups was significant in 3 months. The lumbar and back pain, debilitation, and gait difficulty relieved further in 6 and 9 months after the treatment comparing to those in 3 months, but with no statistical significance. BMD of the lumbar vertebrae, the femur, and the Ward triangle area increased significantly in the study group after 9-month treatment comparing to that before the treatment (P<0.01). BMD of the lumbar vertebrae, the femur, and the Ward triangle area in the control group also increased, but with no statistical difference (P>0.05). After the treatment, BMD among the lumbar vertebrae, the femur, and the Ward triangle area was statistically different (P<0.01). A few patients had adverse reaction including dry mouth and constipation, without obvious hypercalcinemia, liver disfunction, and renal disfunction. Conclusion Jintiange capsule has definite effect without obvious adverse reaction in the treatment of primary osteoporosis. It can not only relieve the lumbar and back pain, the debilitation, and the gait difficulty, but also can increase the BMD and improve quality of life, which is a good choice for clinical medication and has a good prospect. |