| Objective To evaluate the relationship between oxidative stress and bone turnover in the elderly with osteoporosis. Methods A retrospective study was conducted from May 2012 to December 2013. We included 62 cases of elder women (n=32) and men (n=30), with an average age of 72.39 years (62-92 years). There were divided to normal bone mass group (n=14), osteopenia group (n=19), and osteoporosis group (n=29), according to the results of BMD. The blood levels of AOPP, SOD, β-CTX, and tPINP were examined and compared among the three groups using a SPSS 10.0 software. Results The AOPP level in osteoporosis group was higher than that in normal bone mass group and osteopenia group. Meanwhile, the SOD level was the lowest in osteoporosis group (P<0.05). There was no statistical difference among the 3 groups in the values of β-CTX and tPINP. AOPP was negatively correlated with BMD (r=-0.59, P<0.00) and SOD (r=-0.58, P<0.00). On the contrary, AOPP was positively correlated with β-CTX (r=0.31, P<0.02) and age (r=0.53, P<0.00). Importantly, multiple regression analysis revealed that AOPP and SOD were determinant factors to BMD. Conclusion Oxidative stress can cause the disorder of bone metabolism, which is characterized by increasing of bone destruction that affects BMD. It plays an important role in the occurrence and development of osteoporosis in elderly people. Antioxidant therapy may have a certain effect on the disease. |