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| 骨质疏松治疗的直接目标 |
| The direct-goal therapy of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2015.03.001 |
| 中文关键词: 骨质疏松 直接治疗目标 |
| 英文关键词:Osteoporosis Direct therapy goal |
| 基金项目:内蒙自然科学基金项目（2012MS1106) |
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| 中文摘要: |
| 为了优化骨质疏松症(Osteoporosis，OP)的治疗策略，Cummings等学者提出了制定骨质疏松症治疗的直接目标，并认为骨密度(Bone mineral density，BMD)、骨折风险性及骨转换标志物(Bone turnover markers，BTM)可能作为重要的目标参数。这一目标的确立具有重要的临床价值，有利于临床更合理的选择初始治疗的方案，有利于改善患者在治疗中的随诊，有利于更恰当的评估药物对BMD和骨折风险性的效应，而且帮助临床医师决定是否转变治疗方案及何时停药。确立了直接目标，治疗就应以此目标为基准，以最大可能性达到目标的治疗方案作为最合适的治疗选择，并以接近此目标的周期性评估作为最合理的评估方案。尽管确立OP治疗的直接目标尚存在许多亟待解决和有待探讨的问题，它的确立巳成为OP治疗的必然趋势，具有深远的临床意义。故本文就骨质疏松治疗的直接目标及其国内外现状和共识问题做一综述。 |
| 英文摘要: |
| Cummings et al proposes direct-goal therapy of osteoporosis (OP) and regards bone mineral density (BMD)，fracture risk，and bone turnover markers (BTM) as important parameters in order to optimize treatment strategies. The establishment of the goal plays an important role in clinical application，which improves reasonable choice of initial drug therapy and follow-up on treatment，also improves assessment of potent effects on BMD and fracture risk. In addition，it helps clinicians to decide when to switch and when to stop. Once the goal has been established，treatment should follow it. We should choose the treatment that has a reasonable probability of reaching that goal and periodically follow-up to approach the goal as most appropriate programs. Although there are still many problems and issues to be discussed，direct-goal therapy of OP has become an inevitable trend and has far- reaching significance. This paper reviews the direct-goal therapy of osteoporosis and current research consensus. |
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