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| 金天格胶囊治疗阿那曲唑致绝经后乳腺癌患者骨量减少的临床研究 |
| The clinical research of effect of Jintiange capsule on anastrozole-associated osteopenia in the postmenopausal women with breast cancer |
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| DOI：10.3969/j.issn.1006.7108.2015.03.013 |
| 中文关键词: 骨量减少 阿那曲唑 乳腺癌 金天格胶囊 |
| 英文关键词:Osteopenia Anastrozole Breast cancer Jintiange capsule |
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| 中文摘要: |
| 目的 观察金天格胶囊治疗阿那曲唑引起的绝经后乳腺癌患者骨量减少的临床效果。方法 筛选我院符合人选标准的绝经后乳腺癌患者61例，随机分为治疗组和对照组。治疗组：口服阿那曲唑+金天格胶囊（每次3粒，每日3次）+钙尔奇 D(每次1粒，每日1次），连服6月；对照组：口服阿那曲唑+钙尔奇D(每次1粒，每日1次），连服6月。服药前、后应用双能X线骨密度测定仪进行腰椎L1-L4骨密度测定，并进行骨代谢指标检测（包括血清钙、血清碱性磷酸酶)及血常规、肝肾功能、心电图等安全性指标的检查。对治疗结果进行显效，有效，无效评价。结果 治疗组总有效率为74. 19%，对照组总有效率为 50%，治疗组总有效率优于对照组(P <0. 05);治疗后测量两组患者腰椎骨密度及腰椎t值，两组比较差异有统计学意义（P < 0.05)，治疗组优于对照组;骨代谢指标检测方面，两组患者治疗后在血清碱性磷酸酶检测方面差异有统计学意义(P <0. 05)， 治疗组优于对照组;血清钙检测方面，治疗组与对照组比较差异无显著意义(P >0. 05)。结论 金天格胶囊可有效治疗阿那曲唑引起的绝经后乳腺癌患者的骨量减少，改善患者生活质量。 |
| 英文摘要: |
| Objective To observe the therapeutic effect of Jintiange capsule on anastrozole-associated osteopenia in the postmenopausal women with breast cancer. Methods Sixty-one patients were selected according to the inclusion criteria and were randomly divided into the treatment group and the control group. Patients in the treatment group were treated with anastrozole，JTG capsule (3 times per day and 3 capsules each time)，and calcium (once per day and 1 capsule each time) for 6 months. Patients in the control group were treated with anastrozole and calcium (once per day and 1 capsule each time) for 6 months. Bone mineral density (BMD) of L1 L4 was measured before and after the treatment using DEXA. The biochemical parameters including the blood Ca2 + and ALP，the blood count，the function of the liver and kidney，and ECG were also examined. The therapy results were assessed as obviously effective，effective，and non-effective. Results The total effective rate in the treatment group (74. 19% ) was better than that in the control group (50% ). The changes of BMD and ALP in the treatment group were also better than those in the control group，and the difference was statistically significant (P <0. 05). After the treatment，the change of ALP was significantly different between the treatment group and the control group. The changes of the blood Ca2 + between the 2 groups was not significant different (P > 0. 05). Conclusion JTG capsule is effective in the treatment of anastrozole-associated osteopenia in the postmenopausal women with breast cancer. |
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