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| 低氧诱导因子-1α参与骨发育及骨代谢调控的研究进展 |
| Research progress of the regulatory mechanism of HIF-1α in bone development and bone metabolism |
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| DOI：10.3969/j.issn.1006.7108.2015.03.020 |
| 中文关键词: HIF-1α； OPG ； Wnt信号通路；骨发育 骨代谢 |
| 英文关键词:HIF-1α OPG Wnt signaling pathway Bone development Bone metabolism |
| 基金项目:国家自然科学基金（81201367);浦东新区卫生系统重点学科建设资助项目（PWZx2014-09);浦东新区卫生系统学科带头人培养计划（PWRd2012-16 )；上海市自然科学基金(10ZR1427700) |
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| 中文摘要: |
| 低氧诱导因子-lα( hypoxia inducible factor-1α，HIF-1α)是组织细胞在低氧状态下激活相应基因转录的核心调节因子之一，在骨发育和代谢过程中起到非常重要的作用。通过敲除Vhl基因高表达HIF-1α可以促进血管和骨组织的生成，但这一过程的分子机制依然不明确。目前巳知HIF-1α在骨的发育过程中可以调节多种蛋白因子和信号通路，如血管内皮生长因子 (vascular endothelial growth factor，VEGF)和经典Wnt信号通路，而这些蛋白因子和信号通路大多能对细胞的分化、增殖及功能进行调节。本文综述骨组织发育和代谢过程中HIF-1α、Wnt信号通路、骨保护素(osteoprotegerin，OPG)等所起的作用以及它们之间的联系，从而进一步探讨HIF-1α在骨发育及骨代谢调控中的机制。 |
| 英文摘要: |
| Hypoxia inducible factor-1α(HIF-1α) is one of the master regulators of hypoxia reaction，which plays an important role in osteogenesis and bone metabolism. It is known that over-expression of HIF-1α in mature osteoblasts through deletion of the von Hippel-Lindau ( Vhl) gene profoundly increases angiogenesis and osteogenesis，but the molecular mechanism of this process is still unclear. It is known that HIF-1α can regulate many protein factors and the activation of several signaling pathways，such as vascular endothelial growth factor (VEGF) and Wnt signaling pathway. These protein factors and signal pathways play essential roles in the regulation of cell differentiation，proliferation，and function. This review discusses the main function of HIF-1α and its interaction with other protein factors or signaling pathways，including osteoprotegerin (OPG) and Wnt signaling pathway. |
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