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| PI3 K/Akt信号通路在骨质疏松病理过程中的作用 |
| Effect of PDK/Akt pathway on the pathological development of osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2015.03.021 |
| 中文关键词: PI3K Akt FoxO Wnt 骨质疏松 |
| 英文关键词:PI3K Akt FoxO Wnt Osteoporosis |
| 基金项目: |
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| 中文摘要: |
| 磷脂酰肌醇三激酶/蛋白激酶B( PI3K/Akt)信号通路是调节细胞增殖、分化、存活、迁移和代谢过程的最为重要的一个信号通路。越来越多的证据表明，骨组织中的许多信号分子能够选择性激活PI3K/ Akt信号通路的相关基因，通过调控成骨细胞和破骨细胞的活动，破坏骨重建过程中骨形成与骨吸收的动态平衡，在骨质疏松的发生和发展中扮演着非常重要的角色。 |
| 英文摘要: |
| The phosphoinositide 3-kinase and Akt (PI3K/Akt) signaling pathway is the vital pathway responsible for the regulation of the process of cellular proliferation，differentiation，survival，migration，and metabolism. Increasing evidences highlight a pivotal role of diverse proteins in the bone tissue in the development and progression of osteoporosis. These molecules exert an influence in specific activation of gene expression related to PDK/Akt signaling，contributing to unbalance of bone formation and bone resorption in the process of remodeling via regulation of activities of both osteoblasts and osteoclasts. |
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