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| 干扰素-γ在骨免疫系统中作用的研究进展 |
| Research progress in the role of IFN-γ in osteoimmunology |
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| DOI：10.3969/j.issn.1006.7108.2015.03.022 |
| 中文关键词: 骨免疫学 干扰素-γ 成骨细胞 破骨细胞 脂肪细胞 |
| 英文关键词:Osteoimmunology IFN-γ Osteoblasts Osteoclasts Adipocytes |
| 基金项目:国家自然科学基金资助课题（81370981) |
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| 中文摘要: |
| 随着骨免疫学概念的提出和研究的深人，骨骼系统和免疫系统之间相互作用的复杂性巳得到广泛认可，特别是免疫系统直接或间接介导骨骼疾病发生和发展更是成为这一领域的研究热点。干扰素-γ( Interferon-γ，IFN-γ)作为宿主免疫防御的重要环节，不仅具有免疫相关活性，而且能够作用于多种参与骨更新和重建的细胞系，影响其形成和分化。本文将IFN-γ对骨骼细胞形成和分化的影响进行综述。对其作用机制的深人研究有助于加深对骨免疫学这一系统的理解，并为未来骨骼疾病的治疗提供新思路和新策略。 |
| 英文摘要: |
| With the introduction of the term osteoimmunology and the development of related research，the intricate interaction between the skeletal system and the immune system has been widely recognized. Especially the direct or indirect role of immune system in the occurrence and development of bone disease has become a research hot spot. Interferon-γ (IFN-γ) has not only an immune activity as an important part of host defense，but also acts on the cell lineages involving in bone turnover and remodeling by affecting their formation and differentiation. This paper summarizes the effect of IFN-γ on bone cell formation and differentiation. In-depth study of its mechanism contributes to a better understanding of osteoimmunology and provides novel insights as well as therapeutic strategies for bone diseases. |
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