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| 2014年骨质疏松领域进展回顾
——美国骨矿盐研究学会(ASBMR)年会精粹(2014.休斯顿） |
| Review of the advance in osteoporosis field in 2014：Highlights in the annual meeting of American Society for Bone and Mineral Research (ASBMR，Houston，2014) |
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| DOI：10.3969/j.issn.1006.7108.2015.04.001 |
| 中文关键词: 骨质疏松症 糖尿病 骨关节炎 骨转换标志物 骨硬化素 PTH相关蛋白；甲状旁腺素 选择性组织蛋白酶K抑制剂；非典型股骨骨折 下颌骨坏死 序贯治疗 |
| 英文关键词:Osteoporosis Diabetes Mellitus Osteoarthritis Bone Turnover Marker Sclerostin PTH-related protein Parathyroid Cathepsin K inhibitors (Odanacatib) Atypical femur fracture (AFF) Osteonecrosis of the jaw Sequential therapy |
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| 中文摘要: |
| 随着全球研究者和临床医师对骨质疏松症及骨代谢过程的认知逐步提高，骨质疏松领域的研究热点逐渐增多且研究方向逐渐清晰。首先，由于原发性骨质疏松症主要是一类老年性疾病，因此骨质疏松与其他年龄相关的慢性病有密切联系，在抗衰老机制的研究中，可以包含骨质疏松病因与治疗机制的研究;其次，随着现代成像技术的研发、微创器械的开发和其他诊断技术的突破，骨质疏松诊断和骨质量评估从过去单一的平面影像学测量矿物质含量，逐渐过渡到对骨强度、骨微结构、骨材料特性等多维度鉴定，使研究者能更准确地评估骨组织损害程度和药物作用;最后，抗骨质疏松药物治疗日趋靶向化，新药研发从细胞活性水平深入至信号传导通路水平，以提高药物效能，而临床上从单一用药推进至序贯和联合用药，或两者组合的给药策略，以便患者获得最长的骨保护期，并减少长期使用单一药物的严重不良事件。本文笔者回顾了2014年骨质疏松领域的重大研究结果，重点关注以下3方面：（1)骨质疏松与其他慢性病之间的联系；（2)骨质疏松诊断和骨折风险评估；(3)新药研发和临床治疗策略的研究。 |
| 英文摘要: |
| With the increase of the understanding of osteoporosis by global researchers and clinicians，the research hotspot of osteoporosis field increases gradually and the research direction becomes gradually clear. First of all，because primary osteoporosis is mainly a kind of senile disease，it is closely linked to other chronic diseases in the elderly. The study of the anti-aging mechanism includes the study of etiology and mechanism of osteoporosis. Secondly，with the development of modern imaging technology and the breakthrough of minimally invasive devices and other diagnostic technology，the diagnosis of osteoporosis and assessment of bone quality advance from a single plane image to measure mineral content in the past，to the multi-dimension identification of bone strength，bone microstructure，and bone material properties. Researchers can evaluate the extent of bone damage and the effect of drugs more accurately. Finally，the anti-osteoporosis drug therapy becomes more targeted. The research and development of new drugs have advanced from cell activity level to signal transduction level in order to improve drug efficacy. The clinical medication has improved from the single drug use to sequential and combination use of the drug. so that patients obtain long bone protection period and reduced adverse events due to the long-term use of a single drug. The authors review the major findings in the osteoporosis field in 2014. and focus on the following 3 aspects ：1) The correlation between osteoporosis and other chronic diseases ；2) The diagnosis of osteoporosis and assessment of fracture risk；3)New drug development and clinical research of therapeutic strategies. |
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