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| 抗骨质疏松治疗对原发性骨质疏松症患者骨密度及骨折率的影响 |
| The effect of anti-osteoporosis therapy on bone mineral density and fracture rate in patients with primary osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2015.04.008 |
| 中文关键词: 骨质疏松 骨密度 骨折发生率 |
| 英文关键词:Osteoporosis Bone mineral density Fracture incidence |
| 基金项目: |
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| 中文摘要: |
| 目的 通过对132例原发性骨质疏松症患者抗骨质疏松规范治疗1年前后的对比，明确骨质疏松症早期诊断治疗的意义。方法 以我院2011 -2012年间门诊诊治的有完整记录的原发性骨质疏松症患者132例为研究对象，给予正规抗骨质疏松治疗1年，对治疗前后每位患者的临床症状[视觉模拟评分(Visual Analogue Score，VAS)，双能X线吸取测量法(Dual Energy X-ray Absorptiometry，DEXA)测定骨密度（Bone mineral density，BMD )]、骨折发生率进行对比和统计分析。结果 85例 (65%)患者首诊时伴随有腰酸背痛腿抽筋等症状，治疗3个月后明显好转，1年后仅少数人遗留轻度的腰酸背疼，与治疗前差异显著;不论是骨密度绝对值还是T值，治疗前后均有显著性差异;132例患者在1年的治疗期间仅有2例发生新发骨折，占所有患者的1. 51%。结论 正规的抗骨质疏松治疗不仅可以快速显著地改善临床症状，而且可以提高骨密度，并能预防骨折、降低骨折发生率。 |
| 英文摘要: |
| Objective To illuminate the significance of early diagnosis of osteoporosis by comparison of regular anti-osteoporosis therapy for 132 primary osteoporosis patients before and after treatment. Methods Data of 132 osteoporosis patients who received regular anti-osteoporosis therapy for 1 year in the out-patient of our hospital from 2011 to 2012 were collected. Clinical symptom (Visual Analogue Score， VAS)， bone mineral density (Dual Energy X-ray Absorptiometry， DEXA)，and the incidence of fractures before and after treatment were compared and statistically analyzed. Results Backache and leg cramps occurred in 85 patients (65%) at initial diagnosis，which were relieved greatly after 3 - month treatment. Only few patients remained mild back pain after 1-year therapy. Both absolute value of bone mineral density and the T-score changed significantly after the treatment. Only 2 cases of new fracture occurred during the 1-year treatment in 132 patients (1. 51%). Conclusion Regular anti-osteoporosis treatment can not only rapidly relieve the clinical symptoms，but also improve bone mineral density，prevent fractures，and reduce the incidence of fractures. |
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