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| 金天格胶囊治疗早期糖尿病肾病合并骨质疏松症的临床观察 |
| Study on the clinical effect of Jintiange capsule on the treatment of early diabetic nephropathy with osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2015.04.014 |
| 中文关键词: 糖尿病肾病 骨质疏松症 金天格胶囊(人工虎骨粉) |
| 英文关键词:Diabetic nephropathy Osteoporosis Jintiange capsule (bionic tiger-bone powder) |
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| 中文摘要: |
| 目的 观察金天格胶囊(人工虎骨粉)对早期2型糖尿病肾病合并骨质疏松症的临床疗效。方法选择2013年-2014年来我院诊治的早期2型临床糖尿病肾病合并骨质疏松症102例患者，随机分为A、B、C 3组，各组34例。A组：口服金天格胶囊,每次3粒，每日3次;B组：口服碳酸钙D3片600 mg/d、骨化三醇胶丸0. 25 ug/d及阿仑膦酸钠肠溶片70mg/周;C组:在西药治疗组的基础上，服用金天格胶囊，每次3粒，每日3次。各组疗程为24周。比较各组患者治疗前后腰椎（L1 -4)及右侧股骨颈骨密度值(BMD)及骨质疏松症症状评分。结果 骨密度：各组治疗前骨密度检查无统计学差异(P >0.05)。经过治疗后，各组治疗前后比较，差异明显,有统计学意义（P <0.05); A组与B组治疗后比较未见明显差异,无统计学意义（P > 0. 05);C组分别与A组、B组相比，差异明显,有统计学意义（P <0. 05)。骨质疏松症症状评分：各组患者治疗前比较无统计学差异(P >0. 05)。A、C两组治疗后较治疗前显著改善,有统计学意义（P <0. 05);B组治疗后较治疗前未见明显改善（P >0.05）。各组治疗后比较,A组较C组未见明显差异,无统计学意义(P>0. 05); A、C两组分别与B组比较有显著性差异,有统计学意义(P <0. 05)。结论 金天格胶囊能显著改善早期糖尿病肾病合并骨质疏松症患者腰背疼痛、腰膝痿弱、步履艰难等临床症状，促进骨形成，增加骨密度，金天格胶囊联合西药治疗疗效更佳。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of Jintiange capsule ( bionic tiger-bone powder) on early diabetic nephropathy with osteoporosis of type 2 diabetics. Methods A total of 102 type 2 diabetes patients in our hospital, who were diagnosed as early diabetic nephropathy with osteoporosis during 2013 - 2014, were randomly divided into group A, B, and C, with 34 cases in each. The patients in group A received Jintiange capsule 3 pills per time and 3 times per day. The patients in group B received Caltrate D3 600mg per day, calcitriol capsule 0. 25 ug per day, and alendronate sodium 70 mg per week. The patients in group C received Jintiange capsule on the basis of group B. The treatment lasted for 24 weeks. Bone mineral density (BMD) of the lumbar spine (L1 -4) and the right femoral neck and osteoporosis symptom scores were examined before and after the treatment. Results BMD:BMD was not statistically different among the three groups before treatment (P > 0. 05), but it was statistically significant after treatment (P <0. 05). No significant difference between group A and group B was found. However, statistical significance between group C and group A and B was found (P < 0. 05). Osteoporosis symptom scores: Symptom scores of patients among the three groups before treatment had no statistical difference (P > 0. 05). The scores in group A and C after the treatment improved with statistical significance (P <0. 05). After the treatment, symptom scores in group B did not obviously improve, with no obvious difference (P > 0. 05). After the treatment, no difference was found between group A and group C (P > 0. 05). The symptom scores between group A. C. and group B were statistical different (P <0.05). Conclusion Jintiange capsule can significantly relieve the clinical symptoms of early diabetic nephropathy with osteoporosis in patients with type 2 diabetes. such as low back pain. waist knees weak impotent. and trudging. It also promotes bone formation and increases BMD. Combination of Jintiange capsule with Western treatment may achieve better efficacy. |
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